Development of novel tools for modulation of multifactorial plant stress tolerance using key regulators of biotic and abiotic signalling

最近在破译生物和非生物应激信号通路要素之间的调节和相互作用方面取得的进展已经确定了几个调节因子，这些调节因子涉及对多种形式的生物和环境应激的先天免疫和一般防御反应的协调控制。三方合作研究的一个主要目的是验证对这些信号交叉对话的一些关键调控因子进行基于知识的修改是否适合于显著改善多因子植物的抗逆性性状。拟议的项目旨在通过将德国、以色列和巴勒斯坦合作伙伴的具体利益结合在一个多功能科学和技术交流平台上，将生物和非生物应激信号特定领域的基础研究的专门知识、技术发展和独特资源引导到面向应用的发展。该项目重点对编码转录因子、蛋白激酶、天然免疫蛋白酶体调节剂、细胞外和细胞内酶和应激代谢物的候选调节基因进行功能测试，以了解其对致病和渗透应激的保护作用。通过德国伙伴的援助，该项目还旨在加强参与的以色列和巴勒斯坦研究人员及其机构之间的研究交流、互动和持续积极的合作。

Recent advances in deciphering the regulation and interactions between elements of biotic and abiotic stress signalling pathways have identified several regulatory factors that are implicated in coordinate control of both innate immunity and general defence responses to multiple forms of biotic and environmental stresses. A major aim of proposed trilateral collaborative research is to validate whether knowledge-based modification of some key regulators of these signalling cross-talks is suitable for significant improvement of multifactorial plant stress tolerance traits. The proposed project intends to channel know-how, technology developments and unique resources from basic research in specific areas of biotic and abiotic stress signalling to application-oriented developments by combining specific interests of German, Israeli and Palestinian partners in a versatile scientific and technology exchange platform. The project focuses on functional testing of candidate regulatory genes encoding transcription factors, protein kinases, proteasome modulators of innate immunity, as well as extra- and intracellular enzymes and stress metabolites, for their protective effects against pathogenic and osmotic stresses. Through assistance of German partners, the project also aims to strengthen research exchange, interaction and sustained active collaboration between the participating Israeli and Palestinian researchers and their institutions.