Comprehensive Upgrade of a Shared NMR Facility

9601928科伦匹兹堡大学学术研究基础设施(ARI)项目的这一奖项将帮助匹兹堡大学化学系升级现有的500兆赫核磁共振，为三个现有的300兆赫核磁共振获得新的控制台，并为所有核磁共振计算资源建立一个计算机网络。该设备将加强以下领域的研究：(1)有机合成-开发新的合成方法和机理有机化学；海洋天然产物的全合成；自由基化学和具有治疗意义的重要目标分子的合成(2)分子识别和生物有机化学-主客体系统和新分子络合物和自组装系统的新合成；维生素K和E、非Kekule分子和自由基扩环的作用机理；DNA双链和光声量热法的研究；(3)无机分子中的无机化学连接；研究Mo(V)氧桥二聚体的光化学；(4)聚合物化学--罕见结构的聚合物表面活性剂的研究；开环歧化聚合和化学循环。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。

9601928 Curran University of Pittsburgh This award from the Academic Research Infrastructure (ARI) Program will assist the Department of Chemistry at the University of Pittsburgh to acquire an upgrade of the existing 500 MHz NMR, new consoles for three existing 300 MHz NMRs and construction of a computer network for all the NMR computing resources. This equipment will enhance research in a number of areas including the following: (1) organic synthesis - development of new synthetic methods and mechanistic organic chemistry; total synthesis of marine natural products; radical chemistry and synthesis of therapeutically important target molecules (2) molecular recognition and bioorganic chemistry - new syntheses of host-guest systems and new molecular complexes and self-assembling systems; mechanisms of action of vitamins K and E, non-kekule molecules and free radical ring expansion; investigations of DNA duplexes and photoacoustic calorimetry (3) inorganic chemistry - conjugation in inorganic molecules; investigating photochemistry of Mo(V) oxo bridges dimers and (4) polymer chemistry - studies of polymer surfactants of uncommon architecture; ring-opening metathesis polymerization and chemical recycling. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.