NMR Console Upgrades

化学研究仪器和设施计划的这一奖项将帮助科罗拉多州立大学化学系购买两台最先进的核磁共振控制台，以升级现有的300 MHz核磁共振光谱仪，并对AC控制台进行改造，以升级IBM WP-270 MHz核磁共振。该设备将加强以下领域的研究：(1)辅酶B12依赖的核糖核苷酸还原酶的矿物生物化学，(2)修饰寡核苷酸合成方法的发展，(3)基于环丁烯酮化学的非天然核苷类似物的合成，(4)甲酰胺和其他手性碳负离子的合成，(5)高氟化弱配位阴离子的合成和应用，(6)DNA裂解的喹卡菌素机理和(7)钒和磷的生物有机和生物无机化学。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。

This award from the Chemistry Research Instrumentation and Facilities Program will assist the Department of Chemistry at Colorado State University to acquire two state-of-the-art NMR consoles to upgrade existing 300 MHz NMR Spectrometers and retrofit the AC consoles to upgrade the IBM WP-270 MHz NMR. This equipment will enhance research in a number of areas including the following: (1) metallobiochemistry of co-enzyme B12-dependent ribonucleotide reductase, (2) development of methodology for synthesis of modified oligonucleotides, (3) synthesis of unnatural nucleoside analogs based on cyclobutenone chemistry, (4) formamidines and other chiral carbanions, (5) synthesis and application of highly fluorinated weakly coordinating anions, (6) quinocarcin mechanism of DNA cleavage and (7) bioorganic and bioinorganic chemistry of vanadium and phosphorous. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.