Enone-Initiated Nickel-Catalyzed Carbocyclizations

研究工作的重点是使用烯酮引发的， 镍催化的碳环化反应，得到高度 功能化的，复杂的产品，从简单的，现成的 印刷受体. 该方法将被应用于综合 caracyclin的顺式稠合（3.2.0）双环辛烷框架，三环 环骨架的pentalenic酸和环外，三取代 geissoproteinine和Z-异辛酮的烯烃。 教育规划 包括对底特律学校的推广工作， 分子建模和本科课程在线搜索、课程 研究生一级的发展和合作研究生培训 和帕克-戴维斯的顶尖科学家一起工作 有了这个职业奖， 合成有机计划是支持研究和教育 韦恩化学系的约翰蒙哥马利博士的活动 州立大学。 蒙哥马利教授将把他的研究重点放在 镍促进的共轭加成与 作为新环化方案基础的元介导环化 这将导致复杂的环系统的建设， 存在于天然产物中。 教育计划包括创新 高中、本科和高中化学教学方法 研究生水平。

The focus of the research effort is the use of enone-initiated, nickel-catalyzed carbocyclization reactions to afford highly functionalized, complex products from simple, readily available substrates. The methodology will be applied to the synthesis of the cis-fused (3.2.0) bicyclooctane framework of caracyclin, the tricyclic ring skeleton of pentalenic acid and the exocyclic, trisubstituted alkenes of geissoschizine and Z-isositsirikine. The educational plan includes outreach efforts to Detroit schools, the introduction of molecular modeling and on-line searching to undergraduate courses, course development at the graduate level and collaborative graduate training with top scientists at Parke-Davis. With this CAREER award, the Synthetic Organic Program is supporting the research and educational activities of Dr. John Montgomery of the Department of Chemistry at Wayne State University. Professor Montgomery will focus his research efforts on drawing together nickel- promoted conjugate additions with meta-mediated cyclizations as the basis for a new cyclization protocol that will result in the construction of the complex ring systems that occur in natural products. The educational plan includes innovative teaching approaches in chemistry at the high school, undergraduate and graduate levels.