New Carbon-Carbon Bond-Forming and -Cleaving Organometallic Reactions

这项研究的重点是三方面的。 首先， 将开发未活化的末端烯烃的碳铝化。 第二，将讨论几种锆和钛催化的反应。 试探 第三，锆杂环与 将研究单键试剂。 有了这个更新奖，合成有机计划正在支持 普渡大学化学系根岸英一博士的研究 大学 根岸教授将把工作重点放在开发 通过有机金属的新的合成有用的有机转化， 强调催化和选择性。 该方法将导致 制定可用于合成 天然产物，具有有趣生物学特性的化合物， 材料化学感兴趣的化合物。

The focus of this research is three-fold. First the enantioselective carboalumination of unactivated terminal alkenes will be developed. Second, several zirconium- and titanium-catalyzed reactions will be probed. Third, the ring opening reactions of zirconacycles with single-bonded reagents will be investigated. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Ei-Ichi Negishi of the Department of Chemistry at Purdue University. Professor Negishi will focus his work on the development of new synthetically useful organic transformations via organometals with emphasis on catalysis and selectivity. The approach will lead to the production of methodology which can be utilized for the synthesis of natural products, compounds with interesting biological properties and compounds of interest to materials chemistry.