Acquisition of a Quadrupole Ion Trap Mass Spectrometer

*9709233德尔文化学研究仪器和设施计划颁发的这一奖项将帮助加州理工学院化学系获得一台四极离子陷阱质谱仪。该设备将加强多个领域的研究，包括：(1)远程电子转移(ET)反应，(2)多肽和寡核苷酸的双分子和单分子反应，以及(3)应用金属-多肽络合物与双螺旋DNA进行序列特异性结合和反应。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。电喷雾技术的加入将MS的范围扩展到蛋白质和核酸的相对分子质量，远远超过了任何其他技术。电喷雾电离与高分辨率相结合的使用提供了质谱学中可用的最新技术。它为化学家提供了表征化合物的最强大的工具之一。在质谱学中获得这种能力对于开展许多化学领域的前沿研究是至关重要的。***

*** 9709233 DERVAN This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at the California Institute of Technology to acquire a quadrupole ion trap mass spectrometer. This equipment will enhance research in a number of areas including the following: (1) long -range electron transfer (ET) reactions, (2) bimolecular and unimolecular reactions of peptides and oligonucleotides, and (3) application of metal-peptide complexes for the sequence-specific binding and reaction with double helical DNA. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest technique available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry. ***