Potentiometric Sensors and Extradition Media for Carboxylates

这项研究项目由分析和表面化学计划和多学科活动办公室支持，重点关注三个领域，涉及选择性提取和基于分子识别的电位传感器。韦伯教授和他在匹兹堡大学的学生将使用一种组合方法来寻找中分子量多官能团磷酸三酯的混合物，这种混合物可以选择性地提取目标分析物。新型人工阴离子二羧酸盐受体将被开发用于电位型传感器，并将进一步开发用于微萃取的毛细管电泳仪。这项工作将在工业化学、医学、环境化学以及农业和食品科学中得到应用。对于带负电荷的阴离子，目前几乎没有实用的传感器。对这种传感器的需求跨越了许多科学领域的应用，包括环境、农业、医药和化学工业。该项目旨在开发几种策略，通过开发通过分子识别选择性地与阴离子结合的新化合物和化合物混合物，来直接量化和从真实样品基质中提取此类物种。将开发直接传感器，其功能是测量与分析物浓度有关的电位和可用于极小样本量的提取程序。

This research project, supported by the Analytical and Surface Chemistry Program and the Office of Multidisciplinary Activities, focuses on three areas involving selective extractions and potentiometric sensors based on molecular recognition. Professor Weber and his students at the University Pittsburgh will use a combinatorial approach to find mixtures of medium molecular weight polyfunctional phosphate triesters that selectively extract target analytes. Novel artificial receptors for anionic dicarboxylates will be developed for application in potentiometric sensors and the further development of a capillary electrophoresis device for micro-extraction will be pursued. This work will find use in industrial chemistry, medicine, environmental chemistry, and agricultural and food science. There are few practical sensors for anions which are negatively charged species. The need for such sensors spans applications in many areas of science including the environment, agriculture, medicine, and chemical industry. This project aims to develop several strategies for directly quantifying and for extracting such species from real sample matrices by developing new compounds and mixtures of compounds that selectively bind to anions via molecular recognition. Direct sensors that function by measuring potentials that are related to analyte concentration and extraction procedures that can be implemented for very small sample volumes will be developed.