Synthetic and Mechanistic Studies on the Homogeneous Catalysis of Transition Metal Complexes

斯通布鲁克这项研究有两个重点。首先，将通过探索级联三环化反应、捕获硅基碳环化(SiCaC)反应中的中间体以及测试杂化SiCaC反应的范围来开发新的碳环化反应。其次，将开展超临界二氧化碳中均相催化的合成和机理研究。这种方法有望获得更高的反应速率和更高的反应选择性。有了这一续期奖，合成有机计划和多学科活动办公室将支持纽约州立大学石溪分校化学系的Iwao Ojima博士的研究。Ojima教授将专注于开发新的、高效的均相催化反应，将碳环化和羰化与异双金属催化剂系统结合在一起。该方法为合成化学家提供了制备大量环状分子的有力工具。

Stony Brook This research has two foci. First, the development of new carbocyclization reactions will be carried out by probing cascade tricyclizations, by trapping of the intermediates in silylcarbocyclization (SiCaC) reactions and by testing the scope of hetero-SiCaC reactions. Second, a synthetic and mechanistic study of homogeneous catalysis in supercritical carbon dioxide will be carried out. Both higher reaction rates and greater reaction selectivity are to be expected from this approach. With this renewal award, the Synthetic Organic Program and the Office of Multidiciplinary Activities are supporting the research of Dr. Iwao Ojima of the Department of Chemistry at the State University of New York, Stony Brook. Professor Ojima will focus his work on developing new and efficient homogeneous catalytic reactions incorporating carbocyclizations and carbonylations in conjunction with heterobimetallic catalyst systems. The methodology affords synthetic chemists powerful tools for the preparation of a large number of cyclic molecules.