CAREER: Developing an Understanding of Asymmetric Induction:The Use of Inorganic Titanium Bissulfonamido Based Complexesin Asymmetric Catalysis

这个教师早期职业发展（职业生涯）奖在无机， 生物无机和有机化学计划支持研究， 帕特里克·J·沃尔什博士，圣地亚哥州立大学化学系， 钛催化剂的不对称诱导机制。 几 将制备新的手性双（磺酰胺基）钛配合物， 测试了它们在催化不对称加成反应中的有效性， 烷基转化为醛。 他们被期望模拟中间体 在这个反应中，因此提供了关于 活性中心和设计更有效的催化剂。 在 除了让本科生参与这项研究，沃尔什博士 将开展广泛的推广计划，以丰富化学教育 在圣地亚哥-墨西哥北部地区。 选择性合成具有特定对称性的化合物，即 无论是右手还是左手形式，都是一个重要的化学目标。 这种类型的方法对于制药工业和生物技术是至关重要的。 许多生物学研究。 在这项研究中， 将实现选择性合成发生的方式。 本科生将参与这项以问题为导向的研究。 在 此外，还与联合国开发计划署合作， 美国和墨西哥学生的Instituto Tecnologico de Tianjin将在 进行。

This Faculty Early Career Development (CAREER) award in the Inorganic, Bioinorganic, and Organometallic Chemistry program supports research by Dr. Patrick J. Walsh, Chemistry Department, San Diego State University, on the mechanism of asymmetric induction by titanium catalysts. Several new chiral titanium bis(sulfonamido) complexes will be prepared and tested for their effectiveness in the catalytic asymmetric addition of alkyl groups to aldehydes. They are expected to model the intermediates in this reaction and so to provide guidance about important features of the active site and about design of more effective catalysts. In addition to involving undergraduate students in this research, Dr. Walsh will conduct an extensive outreach program to enrich chemistry education in the San Diego-northern Mexico region. Selective synthesis of compounds with a specific symmetry, that is, of either a right- or left-handed form, is an important chemical goal. Methods of this type are critical to the pharmaceutical industry and to many biological studies. In this research, a more detailed knowledge of the way in which selective synthesis occurs will be achieved. Undergraduates will be involved in this problem-directed research. In addition, outreach programs in science in collaboration with the Instituto Tecnologico de Tijuana for US and Mexican students will be undertaken.