Purchase of an Electrospray LC-Quadrupole Ion Trap Mass Spectrometer

通过化学研究仪器和设施（CRIF）计划的这一奖项，布朗大学化学系将获得电喷雾LC四极杆离子阱质谱仪。这一设备将加强若干领域的研究，包括a）聚酮化合物和其他天然产物的生物合成; B）筛选肽基蛋白酶抑制剂组合文库的活性; c）分析参与细胞表面分子识别事件的复杂糖脂; d）研究烯醇化物结构; e）分析用于研究生物化学识别过程的重组表达蛋白质;和f）研究在致癌性中起作用的加合物的结构。 质谱（MS）是一种用于探测紧密结构细节并获得大量有机、生物有机和有机金属分子的分子组成的技术。这些研究的结果将对包括药物化学和生物学在内的许多领域产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Brown University will acquire an Electrospray LC-Quadrupole Ion Trap Mass Spectrometer. This equipment will enhance research in a number of areas including a) the biosynthesis of polyketide and other natural products; b) screening of the activity of a combinatorial library of peptide-based protease inhibitors; c) analysis of complex glycolipids involved in molecular recognition events on cell surfaces; d) investigations of enolate structures; e) analysis of recombinantly expressed proteins used to study biochemical recognition processes; and f) investigations of the structure of adducts that play a role in carcinogenicity. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The results from these studies will have an impact in a number of areas including medicinal chemistry and biology.