SGER:Surface Molecular Imprinting of Synthetic Membranes

摘要：这项为期一年的“探索性研究小额资助”（SGER）的目标是评估两种有前途的分子印迹方法来生产选择性分子识别膜。新方法的预期优势是成本更低，可访问的印记位点数量增加，结合速度明显加快，传质率提高，尾迹减少，以及在水环境中的适用性。采用两种光氧化方法-表面模板和乳液聚合-制备，表征和测试分子印迹合成聚合物膜。首先，对于表面模板聚合，使用伦斯勒理工学院的专利光氧化工艺生产分子印迹聚醚砜（PES）膜。由于PES本身具有光活性，因此不需要光引发剂，从而大大降低了成本，持续时间和过程的复杂性。PES也是最广泛使用的膜聚合物之一，在水环境中可进行表面改性。其次，对于乳液聚合，在将油包水乳液作为薄膜浇铸到平面和微孔合成膜上后，使用紫外线辐射将油相聚合在印记和功能分子周围。最后，在这两种情况下，水和模板都通过微波加热去除，这打开了孔隙，在二维薄膜上留下了印记腔。如果这项工作取得成功，其潜在影响的性质和意义可以概括如下。在传统的亲和分离方法中，必须对主动泛函进行合成，然后将其附加到一个支持矩阵上。原位制造功能化表面可以消除许多加工步骤。这里应用的表面模板聚合和乳液聚合都具有简单、可扩展和廉价的潜力。此外，所得到的薄膜可以有效地与更常见的吸附亲和方法竞争，以完成困难的分离。

CTS-0087053Georges BelfortRensselaer Polytechnic InstituteSGER: Surface Molecular Imprinting of Synthetic Membranes ABSTRACT The goal of this one-year "Small Grant for Exploratory Research" (SGER) is to evaluate two promising methods of molecular imprinting to produce selective molecular-recognition membranes. The expected advantages of the new methods are lower cost, an increased number of accessible imprint sites, significantly faster binding with improved mass transfer rates and reduced tailing, and applicability in aqueous environments. With two photooxidation approaches - surface template and emulsion polymerization - the approach is to prepare, characterize, and test molecular-imprinted synthetic polymeric membranes. First, for surface template polymerization, molecular-imprinted poly(ether sulfone) (PES) membranes are produced using Rensselaer Polytechnic Institute's patented photooxidation process. Since PES is intrinsically photoactive, a photoinitiator is not required, thus reducing the cost, duration and complexity of the process significantly. PES is also one of the most widely used polymers for membranes and is amenable to surface modification in aqueous environments. Second, for emulsion polymerization, after casting of water-in-oil emulsions as a thin film onto flat surfaces and onto microporous synthetic membranes, the oil phase is polymerized around the imprint and functional molecules using UV radiation. Finally, in both cases, the water and templates are removed by microwave heating, which opens up pores and leaves imprinted cavities in a two-dimensional film. The nature and significance of the potential impact of this work, should it succeed, can be summarized as follows. In traditional affinity-separation methods the active functionality must be synthesized and then attached to a support matrix. Fabricating the functionalized surface in situ can eliminate a number of processing steps. Both surface-template and emulsion polymerization as applied here have the potential to be simple, scalable, and inexpensive. Also, the resulting thin membranes could effectively compete with more common adsorption affinity methods to accomplish difficult separations.