Asymmetric Catalysis with Chiral Lewis Bases

本项目探索了各种路易斯酸催化反应的潜力，通过引入手性路易斯碱来促进和呈现催化和/或不对称反应。该方案涵盖的反应类型广泛，直接目标包括不对称醛醛反应和醛烯丙化反应。支持方法学研究的机理研究包括依赖于超临界流体色谱和快速注射核磁共振的动力学研究。有了这个奖项，有机和大分子化学项目继续支持伊利诺伊大学厄巴纳-香槟分校的斯科特·e·丹麦教授的研究和教育活动。丹麦教授在合成和反应机理方面进行基础研究，旨在制备同时控制几个不对称中心立体化学的小分子。此外，化学博士生在现代有机化学的概念和行为方面获得宝贵的知识。

This project explores the potential of various Lewis-acid catalyzed reactions to be promoted and rendered catalytic and/or asymmetric by the introduction of chiral Lewis bases. The types of reactions that this scheme encompasses is extensive, with immediate objectives including asymmetric aldehyde aldol reactions and aldehyde allylation reactions. Mechanistic investigations supporting the methodological studies include kinetic studies relying upon supercritical fluid chromatography and rapid-injection NMR.With this Award, the Organic and Macromolecular Chemistry Program continues its support of the research and educational activities of Professor Scott E. Denmark of the University of Illinois Urbana-Champaign. Professor Denmark conducts fundamental research into synthetic and mechanistic aspects of reactions designed to prepare small molecules controlling the stereochemistry of several centers of asymmetry in a simultaneous fashion. In addition, doctoral students of chemistry gain invaluable knowledge in the conception and conduct of modern organic chemistry.