SBIR Phase I: Immunoconjugate Luminescent Sensors Based on CdTe/CdS Nanoparticles

这个小型企业创新研究(SBIR)第一阶段项目寻求设计一种纳米颗粒-单抗结合物，能够检测包括布鲁氏菌和弗朗西斯氏菌在内的选定生物战剂。这种新的检测方法是有效的、灵敏的、选择性的、廉价的和真正便携的。该系统采用了一种创新的检测方法，涉及两个波长的荧光，进一步提高了选择性和灵敏度。传感器机制使用一种共轭薄膜，可以通过多种方式检测与军事和非军事部门相关的其他病原体。该项目将开发的技术的商业应用将在反恐领域以及必须检测病原体污染的医疗、食品、农业和相关领域。

This Small Business Innovation Research (SBIR) Phase I project seeks to design a nanoparticle-monoclonal antibody conjugate that is capable of detecting select biological warfare agents including Brucella and Francisella. This novel approach to detection is effective, sensitive, selective, inexpensive and truly portable. The system uses an innovative detection method involving two wavelengths of fluorescence, which further increases selectivity and sensitivity. The sensor mechanism uses a thin film of conjugate that can be exploited in a number of ways for detection of other pathogens of relevance to both military and non-military sectors.The commercial applications of the technology to be developed in this project will be in the area of counter-terrorism and in medical, food, agricultural and related fields where pathogen contamination must be detected.