Electro-active and migratory peptides in lipid bilayers: NMR and biophysical studies

所有生物的特征都是通过自组装膜将内部空间与周围介质分离。水、离子和溶质的选择性进出是每种类型细胞的一个决定性特征。一些蛋白质感知细胞膜上的电压差，并根据电压变化打开或关闭。其他的，如细菌毒素聚集在膜上作为孔隙，而其他肽则背着它们的肽货物在膜上迁移。目的是了解这些膜活性肽和蛋白质的分子机制，以便在正常和疾病状态下对其原位操作进行合理干预。

All living things are characterized by the separation of inner space from the surrounding medium by a self-assembling membrane. Selective entry and exit of water, ions and solutes is a defining feature of each type of cell. Some proteins sense the voltage difference across the cell membrane and open or close in response to voltage changes. Others, like bacterial toxins assemble in the membrane as pores, while other peptides migrate across the membrane piggy-backing their peptide cargo. The aim is to understand the molecular mechanisms in examples of these membrane-active peptides and proteins with a view to enabling rational intervention into their operation in situ in normal and disease states.