Synthesis and Development of Shape Selective Reagents

本研究的重点是开发生产分子寄主的合成方法。主机的分析将在两个层面上进行。首先，它们将被研究以评估由于空腔形状和宿主化合物内功能位置而切割保护基团的潜力。其次，研究内部功能化分子胶囊的性质。这种胶囊通过自组装在水中形成，具有在干燥环境中封装类固醇等分子的潜力。通过这个奖项，有机和大分子化学项目支持了新奥尔良大学化学系Bruce C. Gibb博士的研究。吉布博士的短期工作将集中在开发分子宿主的合成方法上，这些分子宿主具有内置在高度凹形结合口袋中的功能。这些现成的宿主将被检查是否有能力分裂共同的保护群。该项目将产生更广泛的影响，因为它是培训研究生，特别是那些来自代表性不足的少数群体的研究生的绝佳场所。此外，这项研究可能会对制药行业产生影响。

The focus of this research involves the development of synthetic methods for the production of molecular hosts. The analysis of the hosts will be carried out on two levels. First, they will be studied to gauge the potential for cleaving protecting groups due to cavity shape and the position of functionality within the host compounds. Second, the properties of internally functionalized molecular capsules will be studied. The capsules, formed in water via self-assembly, possess the potential for encapsulating molecules such as steroids in a primarily dry environment.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Bruce C. Gibb in the Department of Chemistry at the University of New Orleans. Dr. Gibb will focus his work for the short term on developing methodology for the synthesis of molecular hosts that possess functionality built into highly concave binding pockets. These readily available hosts will be examined for the ability to cleave common protecting groups. The project will have broader impact as an excellent venue for the training of graduate students, especially those from underrepresented minority groups. Further, the research could have an impact on the pharmaceutical industry.