SST: Fully-integrated CMOS Biochip Arrays for Multicolor Biomolecular Diagnostics

本研究解决了用于传感生物分子（蛋白质和DNA）的基于cmos的多路荧光传感器的开发。目标是开发传感器密度为每平方厘米一万个传感器的广义平面阵列。研究人员将探索稳态和动态荧光。该传感器将包含由四分之一波长层组成的集成干涉滤波器，用于抑制激发源。研究人员将考虑许多测量问题，并部分受到他们以前使用标记为Imager F1的CMOS生物芯片的经验的指导。这些问题包括利用规模经济来提供低成本设备；优化设备自给自足和小型化，以提供最大的便携性；开发多目标分析物检测的并行设计；使传感器级逻辑检测，校准和控制；优化动态范围、灵敏度和检测速度。现有的技术是在玻片上进行检测化学反应，然后通过外部传感器（或读取器）进行检测。这种设计虽然坚固，但适用于实验室环境。所提出的将传感化学与传感器相结合的方法具有紧凑和便携的潜力。

0428544ShepardThis research addresses the development of multiplexed CMOS-based fluorescence sensors for sensing biomolecules (proteins and DNA). The goal is to develop generalized planar arrays with sensor densities on the order of ten thousand sensors per cm2. The investigators will explore both steady state and dynamic fluorescence. The sensor will contain an integrated interference filter consisting of quarter-wavelength layers for rejecting the excitation source. The investigators will consider many measurement issues, and are guided in part by their previous experience with the CMOS biochip labeled Imager F1. These issues include leveraging of economies of scale to provide low-cost devices; optimizing device self-sufficiency and miniaturization to afford maximum portability; developing parallelized designs for detection of multiple target analytes; enabling sensor-level logic for detection, calibration, and control; and optimizing dynamic range, sensitivity, and speed of detection. The existing technology is to do the detection chemistry on a glass slide, and then to carry out the detection via external sensors (or readers). This design while robust is meant for a laboratory setting. The proposed approach of integrating sensing chemistry with sensors has the potential of being compact and portable.