NANO: Combinatorial Self-Assembly of Nanocircuits on Addressable DNA Nanoscaffolds

该建议旨在开发高度可编程和高效的自下而上。构建纳米电子电路的方法，使用DNA纳米结构作为支架和序列特异性分子光刻作为工具，将金属和半导体纳米线组合地组织成具有自组装功能纳米电子器件的潜在应用的合理设计的集合。设计师DNA纳米支架正在成为创建复杂的纳米粒子的首选材料，具有潜在的能力来图案化具有可寻址性的纳米尺度物体，但它们与功能性纳米材料的成功整合需要跨学科的研究。 拟议研究的智力价值：合理定义的纳米电子电路图案的程序化和有效的自组装是目前纳米技术的突出挑战之一。 该合作项目的主要研究目标是证明基于DNA的自组装可以实现可寻址分子光刻模板的自组装。 已经组建了一个团队，其集体专业知识可以全面解决开发DNA纳米结构作为金属和半导体纳米线集合的空间可寻址模板中最紧迫的问题。本研究的主要目标是：1）设计并实现DNA纳米结构的自组装，形成含有序列特异性模板的图案化晶格，用于基于DNA的分子光刻。 2)填补DNA分子光刻和DNA自组装研究之间的差距，发展高度可编程纳米电子电路的组合方法。自底向上。组装件. 拟议研究的更广泛影响：该项目的更广泛影响包括对未来集成电路和微处理器生产的潜在重大影响。 另外的影响将发生在教育学生有关构建纳米电子系统的各个方面。 将继续努力招收代表性不足的学生，包括少数民族和妇女，并对他们进行基于DNA的纳米技术培训。本科生和高中生也将被招募到这个项目。 我们的成果将通过各种科学出版物、与工业合作伙伴的互动以及杜克大学纳米科学与材料中心进行分发。 将设计一套有凝聚力的课程，解决纳米计算机设备研究的重要方面。这包括DNA纳米技术，纳米电子器件和架构的主题。作为另一个重要的教育组成部分，一个基于DNA的纳米技术网站。将设计面向普通大众的。PI和co-PI的访问有才华的计算机科学学生使我们能够实现这样一个网站与用户友好的界面。DNA纳米技术的影响可以通过将拟议的研究与补充培训和知识转移计划相结合来充分发挥其潜力。一个基于网络的频道将有助于在公共领域推广DNA纳米技术。 该提案福尔斯属于以下EMT主题：通过结合纳米科学和工程的见解，提高计算机和信息科学与工程的基本能力。

This proposal aims to develop highly programmable and efficient .bottom-up. methods for constructing nanoelectronic circuits, using DNA nanoarchitectures as scaffolds and sequence specific molecular lithography as a tool to combinatorially organize metallic and semiconducting nanowires into rationally designed ensembles with potential applications of self-assembling functional nanoelectronic devices. Designer DNA nanoscaffolds are emerging as the material of choice for creating sophisticated nanopatterns with the potential capability to pattern nano-scale objects with addressability, but their successful integration with functional nanomaterials requires interdisciplinary studies. Intellectual merit of proposed research: The programmed and efficient self-assembly of rationally defined nanoelectronic circuit patterns is presently one of the outstanding challenges in nanotechnology. The main research objective of this collaborative project is to demonstrate that self-assembly of addressable molecular lithographic template can be achieved using DNA based self-assembly. A team has been assembled whose collective expertise can comprehensively address the most pressing issues in developing DNA nano-architectures as spatially addressable templates for metallic and semiconducting nanowire ensembles. Two main goals will be achieved through this proposed research: 1) Design and demonstrate self-assembly of DNA nanostructures to form patterned lattices containing sequence specific template for DNA based molecular lithography. 2) Bridge the gap between researches in DNA based molecular lithography and DNA self-assembly to develop combinatorial methods for highly programmable nanoelectronic circuit .bottom-up. assembly. Broader impact of proposed research: The broader impacts of this project include potentially significant influence on the production of future integrated circuits and microprocessors. Additional impact will occur in educating students about the various aspects of constructing nanoelectronic systems. Efforts will be continued in recruiting underrepresented students including minorities and women and train them in DNA based nanotechnology. Undergraduate and high school students will also be recruited to this project. Distribution of our results will occur through various scientific publications, interactions with industrial partners, and through Duke University.s Center for Nano-science and Materials. A cohesive set of courses that address the important aspects of nanoscale computer device research will be designed. This includes topics in DNA Nanotechnology, Nanoelectronic Devices and Architectures. As another important educational component, a .DNA-based nanotechnology web site. aimed at a general public audience will be designed. The PI and co-PI.s access to talented computer science students enable us to implement such a web site with a user-friendly interface. The impact of DNA nanotechnology can be brought to its full potential by integrating the proposed research with a complementary training and knowledge transfer program. A Web-based channel will help promote DNA nanotechnology in the public domain. This proposal falls into the following EMT theme: advance the fundamental capabilities of computer and information sciences and engineering by incorporating insights from nanoscale science and engineering.