NER: Development of Turnip Yellow Mosaic Virus as Nano Delivery Vehicles

0508419王这项建议是对NSF 04-043类纳米科学与工程倡议的响应。这项研究将导致开发将细胞过程与纳米电子器件相耦合的系统。总体目标是加强对大脑动力学的理解，并利用这项研究来设计生物传感器和其他生物医学设备。细胞膜将与半导体和纳米结构相连。视网膜细胞将在3D凝胶基质中培养。基质材料将包含纳米颗粒，如共轭聚电解质、纳米棒和纳米线。聚电解质会在凝胶基质中固化，并固定神经细胞。视网膜细胞将通过使用作为电压敏感型荧光染料的共轭电解质进行活性测试。PI将利用在纳米线阵列生长方面开发的专业知识来生产纳米线凝胶基质。这种结构被设计成未来人工视网膜的模型。纳米管将被用来生产能够提高电子性能的离子传输基质。

0508419WangThis proposal was received in response to Nanoscale Science and Engineering initiative, NSF 04-043, category NER.This research would result in the development of systems that couple cellular processes to nanoelectronic devices. The overall goal is to enhance understanding of brain dynamics and to use this research to design biosensors and other biomedical devices. Cell membranes will be connected to semiconductors and nanostructures. Retina cells will be cultured in a 3D gel matrix. The matrix material will contain nanoparticles, such as conjugate polyelectrolytes, nanorods and nanowires. Polyelectrolytes will solidify in the gel matrix and immobilize the neuron cells. The retina cells will be tested for activity by using the conjugated electrolytes, which serve as voltage-sensitive fluorescent dyes. The PI will use expertise developed in the growth of nanowire arrays to produce the nanowire gel matrices. Such structures are designed to serve as models for future artificial retina. Nanotubes will be used to produce matrices capable of ionic transport for enhanced electronic properties.