Metal-Coordinated Biradicals as Synthetic Intermediates

本项目的重点是开发基于新型金属配位双基中间体的全新合成方法。机械和计算研究将被用来理解最近发现的金属催化的伯格曼环芳构化反应。一个单一的金属中心将被用来诱导双自由基的形成，将立体化学信息传递到遥远的成键位置，并激活相邻的芳环进行随后的立体选择功能化。研究还将包括开发金属触发的杂环-伯格曼环芳构化反应，以形成具有重要合成意义的杂环化合物。通过这个奖项，有机和大分子化学项目支持加州大学圣地亚哥分校化学系约瑟夫·m·奥康纳教授的研究。奥康纳教授的研究工作围绕着基于新型金属配位双基的新合成方法的发展。这种金属配位的双自由基为复杂有机分子的合成提供了有效的途径，也为在没有这种自由基的情况下几乎无法获得的分子的制备提供了希望。

This project is focused on the development of fundamentally new synthetic methodology based on the intermediacy of novel metal-coordinated biradicals. Mechanistic and computational studies are to be employed in order to understand recently discovered metal-catalyzed Bergman cycloaromatization reactions. A single metal center will be employed to induce the formation of biradicals, transmit stereochemical information to remote bond-forming locations, and activate adjacent aromatic rings for subsequent stereoselective functionalization. Studies will also include the development of metal-triggered hetero-Bergman cycloaromatization reactions for the formation of heterocyclic compounds of synthetic importance. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Joseph M. O'Connor of the Department of Chemistry at University of California-San Diego. Professor O'Connor's research efforts revolve around the development of new synthetic methodology based on novel metal-coordinated biradicals. Such metal-coordinated biradicals offer promise for efficient approaches for the synthesis of complex organic molecules as well as the preparation of molecules that are virtually inaccessible in the absence of such radicals.