IRES: U.S.-Danish Cooperative Research and Education in DNA Nanotechnology

这项面向学生的国际研究体验(IRES)活动将北卡罗来纳州杜克大学的研究人员和导师与丹麦奥胡斯大学的同行联系起来。首席研究员Thomas H.LaBean和杜克大学的同事们将与库尔特·V·戈瑟夫领导的丹麦合作伙伴合作，管理一种平衡的、基于团队的纳米技术研究和教育方法。这一整合的合作项目将为美国研究生和本科生提供自组装DNA纳米结构和纳米化学方面的国际研究经验。杜克-奥胡斯IRES模式还包括博士后导师和准备进行研究的高中生。杜克大学的参与者将前往奥胡斯接受各种技术的培训，包括接合化学和为未来的实验所用的材料准备。每个初级参与者都将被分配到旨在为整个计划的研究目标和他们的专业发展做出贡献的项目。IRES计划活动的技术重点反映了美国和丹麦的互补优势。计划中的跨学科工作需要合成化学、DNA结构工程、蛋白质生物化学、材料科学和分子生物学方面的技术知识。杜克大学的团队在开发先进的DNA自组装方面为合作贡献了优势。奥胡斯团队提供DNA引导的有机合成和连接化学方面的专业知识，用于将不同的化合物偶联到寡核苷酸。研究成果和培训经验将从互动中受益匪浅。总体而言，这种合作交流应该会产生结果，提高我们使用DNA自组装组织更广泛种类的纳米材料的能力，并使用复杂的DNA纳米结构编程复杂的纳米化学。IRES的教育价值在于学生参与了他们导师的尖端研究，并接触到了两个杰出机构的集体研究生活。美国和丹麦IRES在分子工程方面的合作实现了培养全球科学家和工程师的计划目标，使美国和欧洲的专家能够在彼此感兴趣和能力很强的领域结合互补的人才并共享研究和教育资源。更广泛的影响包括通过在一个已建立的丹麦卓越中心的学习计划，将美国初级研究人员和学生介绍给国际纳米科技界的领导人。

This International Research Experience for Students (IRES) activity links researchers and mentors at Duke University in North Carolina with counterparts at the University of Aarhus in Denmark. Principal investigator, Thomas H. LaBean, and colleagues from Duke will work with Danish partners, led by Kurt V. Gothelf, to manage a balanced, team-based approach to research and education in nanotechnology. The integrated, collaborative program will provide international research experience for U.S. graduate and undergraduate students in self-assembling DNA nanostructures and nanochemistry. The Duke-Aarhus IRES model also involves post-doctoral mentors and research-ready high school students. Duke participants will travel to Aarhus to be trained in various techniques including conjugation chemistry and preparation of materials for use in future experiments. Each of the junior participants will be assigned projects that are designed to contribute to program-wide research goals as well as their professional development.The technical focus of this IRES program of activity reflects U.S.-Danish complementary strengths. The planned cross-disciplinary work requires knowledge of techniques in synthetic chemistry, DNA structural engineering, protein biochemistry, materials science, and molecular biology. Duke University's team contributes strengths in development of advanced DNA self-assemblies to the collaboration. The Aarhus team provides expertise in DNA-directed organic synthesis and conjugation chemistry for coupling diverse compounds to oligonucleotides. Research results and training experiences will benefit greatly through interaction. Overall, this cooperative exchange should yield results that improve our ability to organize a wider variety of nanomaterials using DNA self-assembly and program sophisticated nanochemistry using complex DNA nanostructures. The educational value of the IRES rests with the students' involvement in their mentors' cutting-edge research and exposure to the collective research life of two outstanding institutions. This U.S.-Danish IRES collaboration in molecular engineering fulfills the program objective of developing global scientists and engineers by enabling experts in the United States and Europe to combine complementary talents and share research and education resources in an area of strong mutual interest and competence. Broader impacts include the introduction of U.S. junior researchers and students to leaders in the international nanotechnology community through a program of study at an established Danish center of excellence.