RUI: Chiral NMR Shift Reagents

贝茨学院的Thomas Wenzel教授在分析和表面化学项目的支持下，继续使用大环宿主（含和不含镧系转移试剂），利用核磁共振（NMR）光谱获得分析物的手性信息。虽然核磁共振本身对分子的手性并不敏感，但它可以与大环结合使用，从而提供能够确定确切三维结构的环境。测定某些化合物的光学纯度和独特的绝对构型对制药和其他生化工业极为重要。因此，在这个项目中，本科生接受有关工业相关主题的合成和核磁共振方法的培训。

Professor Thomas Wenzel of Bates College is supported by the Analytical and Surface Chemistry program to continue work using macrocyclic hosts with and without lanthanide shift reagents to obtain information about the chirality of analytes using Nuclear Magnetic Resonance (NMR) spectroscopy. While NMR is not inherently sensitive to the handedness of molecules, it can be used in combination with macrocycles that provide environments enabling the exact three dimensional structures to be determined. Determination of the optical purity and unique absolute configurations of certain chemical compounds is extremely important for the pharmaceutical and other biochemical industries. Thus, in this project undergraduate students receive training in synthesis and NMR methods on an industrially relevant topic.