MRI: Acquisition of a Liquid Chromatograph Electron Spray Ionization Mass Spectrometer

弗吉尼亚理工学院和州立大学化学系将从主要研究仪器项目中获得一台液相色谱仪电喷雾电离质谱仪（LC-ESI-MS）。这将用于多种研究项目，包括：生物活性天然产品的研究；紫杉醇衍生物；自由基离子与单分子重排；二肽硼酸作为疟疾蛋白酶抑制剂的研究合成方法与药物化学；构象约束肽模拟物；碳质纳米材料;树突状硫酸盐作为局部抗感染药物；分子磁体;光收集超分子组件；假轮烷、轮烷和聚轮烷；高分子合成;高氟Diels-Alder聚苯乙烯。质谱是物理和生物科学家使用的一种基本工具，通过精确测量材料和化学物质在仪器中蒸发和电离时的质量和破碎模式，来识别和表征它们。液相色谱是一种分离技术，在引入质谱仪之前将复杂的混合物分离成单独的成分。这些都是重要的工具，应该被引入到年轻科学家的培训中。该仪器将由本科生和研究生以及博士后在他们的研究中实际使用。

The Chemistry Department at Virginia Polytechnic Institute and State University will acquire a liquid chromatograph electrospray ionization mass spectrometer (LC-ESI-MS) with this award from the Major Research Instrumentation program. This will be used in a diverse body of research projects including studies of: bioactive natural products; derivatives of paclitaxel; radical ions and unimolecular rearrangements; dipeptide-borinic acids as malarial protease inhibitors; synthetic methods and medicinal chemistry; conformationally constrained peptide mimics; carbonaceous nanomaterials; dendritic sulfates as topical anti-infectives; molecular magnets; light-harvesting supramolecular assemblies; pseudorotaxanes, rotaxanes and polyrotaxanes; macromolecular synthesis; highly fluorinated Diels-Alder polyphenylenes.Mass spectroscopy is a basic tool used by physical and biological scientists to identify and characterize materials and chemical species by accurate measurement of their mass and fragmentation patterns as they are vaporized and ionized in the instrument. Liquid chromatography is an isolation technique that separates a complex mixture into individual components before introduced to the mass spectrometer. These are important tools to be introduced into the training of young scientists. This instrument will be used hands-on by undergraduate and graduate students, and post docs in their research.