Refurbishment of the 600 MHz NMR at the Mississippi Magnetic Resonance Facility at Mississippi State University

该奖项由2009年美国复苏和再投资法案(公法111-5)资助。在化学研究仪器和设施：多用户计划(CRIF：MU)的支持下，密西西比州立大学化学系将翻新和电脑增强一台600 MHz核磁共振(核磁共振)光谱仪。它将被用于广泛的研究项目，支持结构、反应和分析研究，如1)抗癌植物成分的合成；2)盐对酶稳定性、活性和灵活性的影响；3)速激肽产生信号激活和速激肽受体脱敏的机制；4)生物质快速热解产生的燃料和化学品；5)大规模合成具有巴克敏斯特富勒烯表面碳骨架的多核芳烃(PAHs)；以及6)形成单链分子内折叠结构(G-四链体)的癌基因的生物物理研究。多核核磁共振波谱是化学和生物化学研究中必不可少的分析工具。这些光谱使研究人员能够识别未知物质，并通过检测原子的核自旋性质引起的能级之间的跃迁，提供从小分子到大蛋白质的各种物种中的原子排列和结构信息。这台光谱仪将加强密西西比州的许多项目，促进本科生和研究生的教与学。该仪器将固定在密西西比州立大学的密西西比磁共振设施(MS-MRF)。它将被密歇根州立大学4所学院的7个系、几个生物研究所以及密西西比大学、密西西比医学中心和该地区其他8个参与机构的研究人员使用。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With support from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Department of Chemistry at Mississippi State University will refurbish and cyber enhance a 600 MHz nuclear magnetic resonance (NMR) spectrometer. It will be employed in a wide variety of research projects, supporting structural, reaction, and analytical studies such as 1) the synthesis of anti-cancer plant constituents; 2) the impact of salt on enzyme stability, activity and flexibility; 3) the mechanisms by which tachykinin peptides produce signal activation and desensitization of tachykinin receptors; 4) fuels and chemicals from fast pyrolysis of biomass; 5) the large-scale synthesis of polynuclear aromatic hydrocarbons (PAHs) with carbon frameworks that can be identified on the buckminsterfullerene surface; and 6) biophysical studies of oncogenes that form single stranded intramolecular folded structures known as G-quadruplexes. Multinuclear NMR spectroscopy is an essential analytical tool in chemistry and biochemistry research. The spectra enable researchers to identify unknown substances and to provide information on the atom arrangement and structures in species ranging from small molecules to large proteins by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This spectrometer will enhance many Mississippi State programs that promote teaching and learning of undergraduates and graduate students. The instrument will anchor the Mississippi Magnetic Resonance Facility (MS-MRF) at Mississippi State University. It will be used by 7 departments in 4 Colleges at MSU, several bio-institutes, as well as researchers at the University of Mississippi, the Mississippi Medical Center and eight other participating institutions in the region.