Novel Tandem Reactions

该项目将继续开发使用有机锌试剂形成C-C键的方法，因为C-C键的形成在有机合成中具有基本的重要性。醛直接转化为烯醛的新的有效方法将被研究，这是有机催化反应最重要的起始原料之一。还将探索立体专一性合成富含对映体的烯胺的方法。最后，通过新的卤代环丙烷反应，将合成新的富含对映体的环丙烷。通过这一奖项，有机和高分子化学项目支持宾夕法尼亚大学化学系帕特里克·J·沃尔什教授的研究。沃尔什教授的研究工作包括开发形成C-C键的新颖而实用的方法。这种化学反应将允许在不分离或提纯中间体的情况下进行多种反应，从而减少化学合成对环境的影响。这些方法的成功开发将对制药和农业中的有机合成产生积极的影响。

This project will continue work on the development of methods for the formation of C-C bonds using organozinc reagents, as the formation of C-C bonds is of fundamental importance in organic synthesis. New and efficient methods will be studied for the direct conversion of aldehydes into enals, which are among the most important starting materials for organocatalytic reactions. Methods for the stereospecific synthesis of enantioenriched enamines will also be explored. Finally, new classes of enantioenriched cyclopropanes will be prepared through novel halocyclopropanations. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Patrick J. Walsh of the Department of Chemistry at the University of Pennsylvania. Professor Walsh's research efforts involve the development of novel and practical methods for the formation of C-C bonds. Such chemistry will allow multiple reactions to be performed without isolation or purification of intermediates, thus reducing the environmental impact of chemical synthesis. Successful development of these methods will positively impact organic synthesis in the pharmaceutical and agricultural industries.