EFRI-CBE: Biological, Chemical, and Mechanical Surface Cues for Cell Migration, Proliferation, and Differentiation: An Integrated Approach to Regeneration of New Tissues

项目名称：C.T. Laurencin机构：弗吉尼亚大学主校区提案号：0736002 EFRI-CBE：细胞迁移，增殖和分化的生物，化学和机械表面线索：新组织再生的综合方法摘要本项目将加强对纳米尺度线索在细胞粘附和分化中的作用的科学理解。正如在试验台中所示，这种对这些线索的新理解可以应用于三维聚合物支架的构建，用于修复复杂组织，如韧带和神经，这些组织需要更高程度的精度才能获得足够的愈合和再生。其动机是专注于韧带和神经修复基质的研究，以满足至关重要的临床需求，并以这种方式对美国国家科学基金会在新兴研究和创新领域的努力产生重大影响。许多患有肌肉骨骼结缔组织和神经损伤的人过着痛苦的残疾生活。通过创新的方法，设计、合成和评估新的合成结构，以精确的规格设计，代表了下一代纳米级组织工程。这些新兴技术非常适合于那些依赖于其复杂结构来完成功能恢复的组织的再生，由于其固有的复杂性，迄今为止已被证明是修复的不可逾越的挑战。该提案的额外优势来自其跨学科团队先前的成就，通过整合聚合物化学，材料科学，计算建模和干细胞生物学的专家，并利用这些工具实现一个统一的目标。这项工作将对纳米技术和组织再生领域产生重大影响。组建团队的内在使命将是确保不仅在研究界，而且在教学、培训和教育方面感受到这种影响。特别关注的是将代表性不足的少数民族纳入其影响范围。通过将科学和教育目标结合起来，人们希望实现这一目标。在过去的几年里，首席研究员的实验室已经在高中、本科和研究生阶段培训了80多名少数民族学生，并关注少数民族的招聘、培训和指导。

PI name: C.T. Laurencin Institution: University of Virginia Main Campus Proposal Number: 0736002 EFRI-CBE: Biological, Chemical, and Mechanical Surface Cues for Cell Migration, Proliferation, and Differentiation: An Integrated Approach to Regeneration of New TissuesAbstractThis project will enhance the scientific understanding of the role of nanoscale cues on cell adhesion and differentiation. As illustrated in the testbeds, this new understanding of these cues can be applied towards the construction of three-dimensional polymer scaffolds for the repair of complex tissues such as ligament and nerve, tissues that require a greater degree of precision for adequate healing and regeneration. The motivation is to focus specifically on matrices for ligament and nerve repair stem from vital clinical need and in this way will be of significant impact on the NSF effort in Emerging Frontiers in Research and Innovation. Many individuals suffering from musculoskeletal connective tissue and nerve injury live painful disabled lives. The design, synthesis, and evaluation of novel synthetic constructs engineered to precise specifications through innovative methodologies represent the next generation of nanoscale tissue engineering. These emerging technologies are ideally-suited to the regeneration of those tissues that depend on their complex structure for complete functional restoration, and thus far have proven an insurmountable challenge to repair due to their inherent complexity. Additional strength of this proposal comes from the previous accomplishments of its interdisciplinary team by integrating experts in polymer chemistry, materials science, computational modeling, and stem cell biology and utilizing each of these tools toward one unified objective. The proposed work will have a significant impact on the field of nanotechnology and tissue regeneration. Inherent in the mission of the assembled team will be to ensure that this impact is felt not only in the research community but also in teaching, training, and education. Of particular focus is the inclusion of underrepresented minorities in the scope of its impact. By encompassing scientific and educational goals one hopes to achieve this. The Principal Investigator's laboratory has trained over 80 minority students at the high school, undergraduate, and graduate levels over the past several years, with attention to minority recruitment, training, and mentorship.