New Advances in Rhodium Carbenoid Chemistry

本研究的重点是开发一种通过类卡宾诱导的CH插入来实现CH功能化的实用催化方法。该项目包括设计新的手性催化剂，以及将不寻常的类卡宾转化为有用的合成方法。此外，还将进行进一步研究，以进一步确定Rh诱导的CH功能化的范围，重点是提炼区域选择性CH功能化的控制元件，并拓宽可用于这种化学的给体/受体Carbenid的范围。通过这一奖项，有机和高分子化学计划支持纽约州立大学布法罗分校化学系的Huw M.L.Davies博士的研究。戴维斯博士将把工作重点放在开发金属催化的不对称转化方法上。这项研究将强调使用给体/受体取代的卡宾来扩大C-H插入化学的范围。该项目可能对制药和精细化工行业产生更广泛的影响，该工作为本科生、研究生和博士后助理的培训提供了一个极好的场所。

The focus of this research is to develop a practical catalytic method for CH functionalization by means of carbenoid-induced CH insertion. This project covers the design of new chiral catalysts and the application of unusual carbenoid transformations into useful synthetic methods. Studies will also be conducted to further define the scope of rhodium-carbenoid induced CH functionalization with emphasis on refining the controlling elements for regioselective CH functionalization and broadening the range of donor/acceptor carbenoids that can be used in this chemistry.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Huw M.L Davies of the Department of Chemistry at SUNY at Buffalo. Dr. Davies will focus his work on the development of methodologies for metal catalyzed asymmetric transformations. The use of donor/acceptor-substituted carbenoids to increase the scope of C-H insertion chemistry will be highlighted by this research. The project has potential broader impact for the pharmaceutical and fine chemicals industries and the work provides an excellent venue for the training of undergraduates, graduate students and postdoctoral associates.