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Engineering peptides into superglues selective for target proteins

Engineering peptides into superglues selective for target proteins
将肽工程化为对目标蛋白具有选择性的强力胶
批准号:
DP160104442
负责人:
Prof David Fairlie
金额:
$37.48万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31

项目摘要

项目成果

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中文摘要
翻译
该项目旨在发现如何为未来的研究工具、药物、生物传感器和诊断创造长效肽。目前,多肽被普通社区视为可注射的提高成绩的药物,由于它们不会持续很长时间,因此很难检测到。然而,多肽有许多潜在的好处,这些好处很难获得,因为它们的作用时间很短。该项目旨在开发将多肽形状工程化为纳米级超胶的方法,使其更紧密但有选择性地附着在目标蛋白上,从而延长其作用时间。超强胶工程技术将为未来的研究工具、药物、诊断和生物传感器提供概念验证和原型。
英文摘要
This project aims to discover how to create long-acting peptides for future research tools, drugs, biosensors and diagnostics. Peptides are currently viewed by the general community as injectable performance-enhancing drugs which are difficult to detect because they don't last very long. However, peptides have many potential benefits that are difficult to obtain because of their short durations of action. This project aims to develop ways of engineering peptide shapes into nanoscale superglues that stick more tightly but selectively to their target proteins, thereby extending their durations of action. Technology for engineering superglues would produce proof of concept and prototypes for future research tools, drugs, diagnostics and biosensors.
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