NSF/FDA Scholar-in-Residence at FDA: Neuromechanical outcomes from next generation peripheral nerve implants

1042522 Shah这项研究将有助于制定综合标准，以评估新一代神经植入物的有效性和安全性。在这些标准的发展中，他们将发展对神经生物力学，形态学和电生理功能之间关系的基本见解。我们项目的几个方面是变革性的。他们开发了一种严格的定量方法来直接检查体内神经结构-功能关系。这将弥补文献中关于神经结构对功能影响的许多空白。他们还将使用运动学分析将我们对神经变形的测量校准到基准生理参考系，从而可以在不同物种或不同实验配置中缩放和比较相对神经变形。这种方法代表了一个逻辑和必要的转变，从任意或非标准化的神经应变和应变率在以前的周围神经可塑性的研究报告。实验设计的几个要素是创新的，包括神经电极植入与体内生物力学和电生理测量的集成，以及使用细胞元素，如丰塔纳带，以评估区域神经变形。

1042522ShahThis research will enable the development of comprehensive criteria to evaluate the efficacy and safety of a new generation of neural implants. In the development of such criteria, they will develop fundamental insight into the relationship between nerve biomechanics, morphology, and electrophysiological function. Several aspects of our project are transformative. They have developed a rigorous quantitative approach to directly examine in vivo nerve structure-function relationships. This will bridge numerous gaps in the literature regarding influences of nerve architecture on function. They will also use kinematic analysis to calibrate our measurements of nerve deformation to a baseline physiological frame of reference, allowing one to scale and compare relative nerve deformation across species or in different experimental configurations. This approach represents a logical and necessary shift from arbitrary or non-normalized nerve strains and strain rates reported in previous studies of peripheral nerve plasticity. Several elements of the experimental design are innovative, including the integration of nerve electrode implantation with in vivo biomechanical and electrophysiological measurement, and the use of cellular elements such as Bands of Fontana to assess regional nerve deformation.