Oxidative Enamine Catalysis in Organic Synthesis

新墨西哥大学化学与化学生物学系王伟教授将在化学系化学合成项目资助下，探索形成C-C和C=C键的“氧化烯胺催化”新策略。该合成策略可以用于探索许多新的级联反应，以产生结构多样化和生物学上有趣的构建块和分子结构。本课题的成功完成将为有机合成和分子构建的实践提供强大的合成工具，在制药、化学、农业和生物科学等领域尤其有用。这项研究对化学合成有更广泛的影响，因为它使在温和的反应条件下，从简单易得的化学物质中容易地和原子经济地合成多功能的构建块成为可能。此外，“一锅”级联方法制造复杂的分子结构将解决现代有机合成中的重要挑战，即提高合成效率，使用可持续和廉价的化学品，避免有毒物质，减少废物和危险副产品。最后，通过将研究成果和实验纳入本科教学实验室，以及通过让研究生参与进来，在培养历史上代表性不足的本科生方面也表现出了更广泛的影响。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Wei Wang of the Department of Chemistry and Chemical Biology at University of New Mexico will explore new strategies termed "oxidative enamine catalysis" for the formation of C-C and C=C bonds. The synthetic strategy can be explored for a number of new cascade reactions to generate structurally diverse and biologically interesting building blocks and molecular architectures. Successfully accomplishing the project will provide powerful synthetic tools for the practice of organic synthesis and molecule constructions, which are particularly useful in the fields of pharmaceutical, chemical, agricultural industry, and biological sciences. The research has a broader impact on chemical synthesis by enabling the facile and atom-economic synthesis of versatile building blocks from simple and readily available chemicals under mild reaction conditions. Furthermore, "one-pot" cascade ways to make complex molecular architectures will address the important challenges in modern organic synthesis that are the improvement of synthetic efficiency, the use of sustainable and inexpensive chemicals, the avoidance of toxic agents, and the reduction of waste and hazardous byproducts. Finally, the broader impacts are also demonstrated in training historically underrepresented undergraduate students, by incorporating research results and experiments into undergraduate teaching labs, and by involving graduate students.