CCI Center in Selective C-H Functionalization

选择性C-H官能化中心(CCHF)将开发新的反应和合成方法，以激活和功能化碳-氢键。碳氢键传统上被认为是惰性的，但最近的进展表明，这种键可以被有效地利用。一个多方面的研究团队将建立开发下一代选择性催化剂所需的机理理解，并将开发预测模型，以确定复杂目标合成中的位置选择性。C-H修饰的新催化剂系统和新方法将在天然产物合成、文库制备和药物发现以及材料制备的背景下受到挑战和改进。选择性C-H键功能化也将被广泛研究并进一步发展，用于一步定制已知分子的结构和物理性质。C-H官能化领域预计将影响精细化工行业，有可能彻底改变针对药物和材料的合成策略。通过与行业领先者和其他主要研究中心的合作和伙伴关系，CCHF将确保将基础研究的发现转化为商业创新。整个中心致力于继续教育化学界关于这种新化学的合成潜力，这将促进超出拟议研究范围的创新的发展。该中心还将在化学界以外的领域发挥积极作用，让年轻学生、公众和代表不足的受众参与发展对化学科学的理解和欣赏。通过一个新颖的“化学交流”计划，CCHF将教育和培训他们的科学家，让他们了解向不同受众传播科学的最佳实践。该计划产生的产品，如博客、科学动画和科学新闻，将有助于教育不同的受众(普通公众、高中教师、K-12学生)了解CCHF的研究发现，使该中心处于独特的地位，对全国对化学的看法产生积极影响，并使追求化学职业的人融入更多的多样性。课程开发、研究机会和研究伙伴关系将进一步增强中心对学生和代表不足的少数群体的参与的影响力。选择性C-H功能化中心是化学创新中心(CCI)计划的一部分。

The Center for Selective C-H Functionalization (CCHF) will develop new reactions and synthetic methodologies for activating and functionalizing carbon-hydrogen bonds. The carbon-hydrogen bond has traditionally been considered inert, but recent advances have shown that this bond can be productively exploited. A multi-faceted research team will build the mechanistic understanding required for the development of next-generation, selective catalysts and will develop predictive models for determining site selectivity in complex target synthesis. New catalysts systems and new methods for C-H modification will be challenged and refined in the context of natural product synthesis, library preparation and drug discovery, and materials preparation. Selective C-H bond functionalization will also be extensively investigated and further evolved for the single-step tailoring of the structure and physical properties of known molecules.The field of C-H functionalization is projected to impact the fine chemicals industry, with the potential of revolutionizing synthetic strategies targeting pharmaceuticals and materials. By collaboration and partnership with industry leaders and other major research centers, CCHF will ensure the translation of discoveries in basic research to commercial innovations. A Center-wide commitment to continuing educating of the chemical community on the synthetic potential of this new chemistry will facilitate the development of innovations that lie beyond the scope of the proposed research. The Center also will take an active role in reaching out beyond the chemistry community to engage young students, the public, and underrepresented audiences in developing an understanding of and appreciation for the chemical sciences. Through a novel "Chemistry Communications" program, CCHF will educate and train their scientists on the best practices in communicating science to different audiences. Products generated by this program such as blogs, science animations, and science journalism will serve to educate different audiences (general public, high school teachers, K-12 students) about CCHF's research discoveries, placing the Center in a unique position to make a positive impact on the perception of chemistry in the Nation and the inclusion of more diversity in people pursuing careers in chemistry. Course development, research opportunities, and research partnerships will further enhance the influence that the Center will have on the engagement of students and underrepresented minorities.The Center for Selective C-H Functionalization is funded as part of the Centers for Chemical Innovation (CCI) program.