Chemistry at the Alkyne - Carbene Intersection

在美国国家科学基金会化学结构、动力学和机理项目（CSDM）的资助下，加州大学圣地亚哥分校的约瑟夫·m·奥康纳教授将领导一个研究项目，研究金属环丁烯和乙烯基碳化合物的化学性质。这类配合物已被广泛提出作为金属催化反应的中间体或过渡态结构，影响着有机合成、聚合物化学、制药、材料科学和理论等领域。这种方法将涉及综合、结构、计算和机械工作的结合。目标分子的选择是为了最大限度地提高后续反应活性的潜力，并揭示新的和现有的化学转化的机制特征。提出的化学将推进有机，无机和有机金属过程的基础知识基础，并有助于未来在具有有用性质的分子的环境友好型构建方面取得进展。拟议研究的一个关键目标是培养有机金属化学领域的研究生，使他们能够为工业和学术努力做出重要的科学贡献。

With the support of an award from the Chemical Structure, Dynamics and Mechanism Program (CSDM) at the National Science Foundation, Professor Joseph M. O'Connor of the University of California, San Diego will lead a research program that will investigate the chemistry of metallacyclobutene and vinylcarbene complexes. Such complexes have been widely proposed as intermediates or transition state structures in metal-catalyzed reactions that impact the fields of organic synthesis, polymer chemistry, pharmaceuticals, material science and theory. The approach will involve a combination of synthetic, structural, computational and mechanistic work. Targeted molecules are chosen to maximize the potential for subsequent reactivity and to reveal mechanistic features of new and existing chemical transformations. The proposed chemistry will advance the fundamental knowledge base of organic, inorganic, and organometallic processes, and contribute to future advances in the environmentally friendly construction of molecules with useful properties. A key objective of the proposed studies it the interdisciplinary training of graduate students in the area of organometallic chemistry which will position them to make important scientific contributions to both industrial and academic endeavors.