MRI: Acquisition of a single-crystal diffractometer for the University of Minnesota

来自明尼苏达大学双城分校的John Ellis教授及其同事Lawrence Que、William Tolman、卡尔文孙和Connie Lu将获得一台带有紧凑型铜辐射源的单晶衍射仪，光子探测器和能够收集非常小的标本的高分辨率衍射数据的顶级低温恒温器。该提案旨在加强各级的研究、培训和教育，特别是在以下领域：（a）碳氢化合物稳定的金属原子试剂;（B）电子转移分子催化剂;（c）金属铜酶的生物无机研究和可持续聚合材料的合成;（d）药物的物理机械特性的研究和优化;（e）非血红素铁金属酶的模型复合物;（f）非血红素铁金属酶的模型复合物。（f）生物活性剂的设计;（g）生物活性化合物的合成路线;（h）Pro-Leu-Gly-NH 2和多巴胺受体调节研究和炭疽毒素致死因子抑制;和（i）孤雌菊和海伦娜林类似物的研究。X射线衍射仪允许精确和精确地测量分子的全部三维结构，包括键距和键角，并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。该仪器将成为教学和研究的一个组成部分，不仅在明尼苏达大学，而且在双子城地区的邻近学院和大学。

With this award from the Major Research Instrumentation Program that is co-funded by the Chemistry Research Instrumentation and Facilities (CRIF) Program, Professor John Ellis from University of Minnesota-Twin Cities and colleagues Lawrence Que, William Tolman, Calvin Sun and Connie Lu will acquire a single crystal diffractometer with a compact copper radiation source, photon detector and a top-of-the-line cryostat capable of collecting high-resolution diffraction data on very small specimens. The proposal is aimed at enhancing research training and education at all levels, especially in areas such as (a) hydrocarbon-stabilized metal-atom reagents; (b) electron-transfer molecular catalysts; (c) bioinorganic studies of metallo-copper enzymes and synthesis of sustainable polymeric materials; (d) study and optimization of the physico-mechanical properties of drugs; (e) model complexes of non-heme iron metalloenzymes; (f) design of biologically active agents; (g) synthetic routes to biologically active compounds; (h) Pro-Leu-Gly-NH2 and dopamine receptor modulation study and anthrax toxin lethal factor inhibition; and (i) study of parthenolide and helenalin analogues.An X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research not only at the University of Minnesota but also at neighboring colleges and universities in the Twin Cities area.