Smart Material Advances and Advanced Research Training (SMAART) Workshop

ID: MPS/DMR/BMAT(7623) 1253893 PI: Henderson， James ORG：锡拉丘兹大学标题：智能材料进展和高级研究培训（SMAART）研讨会知识价值：该项目为汉普顿大学研讨会的四名参与者提供支持，他们将被纳入锡拉丘兹大学生物材料研究所正在进行的研究项目的研究。这些学生将在PI的直接监督下，与雪城大学经验丰富的研究生一起工作。他们将学习使用图像分析技术来研究形状变化底物上的集体（紧急）细胞行为，并使用活细胞荧光成像技术来研究这些底物上的个体细胞行为。因此，参与者将被介绍下一代形状记忆聚合物衬底，包括用于研究细胞极性建立的微图案形状记忆衬底，用于研究细胞对衬底刚性响应的时间方面的模量变化形状记忆衬底，以及用于细胞片工程的扩展和收缩衬底。这些动手，尖端的生物材料实验室的经验将通过基础细胞生物学和聚合物科学的研讨会式的讨论和介绍提供给谁希望追求工业，政府或学术界的STEM职业的学生的多种选择补充。更广泛的影响：该项目的科学和技术更广泛的影响将有助于基于形状记忆聚合物的材料的发展，可用于指导干细胞和其他前体细胞的分化。显然，在这种情况下，更重要的是教育和推广更广泛的影响，即为HBCU的学生提供参与组织工程领域前沿研究的机会。PI与汉普顿大学的Raymond Samuel教授之间建立了有效的合作，以确保适当选择讲习班的参与者。研讨会参与者还将能够从最近资助的锡拉丘兹生物材料研究所REU网站的活动中受益。

ID: MPS/DMR/BMAT(7623) 1253893 PI: Henderson, James ORG: Syracuse UniversityTitle: Smart Material Advances and Advanced Research Training (SMAART) WorkshopINTELLECTUAL MERIT: The project provides support for four Hampton University workshop participants who will be integrated into the research of the research program under way in the Syracuse University Biomaterials Institute. These students will be under the direct supervision of the PI and working together with experienced Syracuse graduate students. They will learn to use image analysis techniques to investigate collective (emergent) cell behaviors on shape-changing substrates and to use live-cell fluorescence imaging techniques to investigate individual cellular behaviors on these substrates. The participants will thus be introduced to next-generation of shape-memory polymer substrates, including micropatterned shape-memory substrates for the investigation of cell-polarity establishment, to modulus changing shape-memory substrates for investigation of the temporal aspects of cell response to substrate rigidity, and to expanding and contracting substrates for cell sheet engineering. These hands on, cutting edge biomaterials laboratory experiences will be supplemented through seminar style discussions of the underlying cell biology and polymer science and an introduction to the multiple options available to students who wish to pursue STEM careers in industry, government, or academia.BROADER IMPACTS: The scientific and technical broader impacts of the project will be contributions toward the development of materials based on shape memory polymers that can be used to direct the differentiation of stem and other precursor cells. Clearly more important in this case are the educational and outreach broader impacts, namely, the opportunities provided for students from an HBCU to participate in research at the forefront of the tissue engineering field. An effective collaboration has been established between the PI and Prof. Raymond Samuel of Hampton University that will ensure appropriate selection of workshop participants. Workshop participants will also be able to benefit from activities of the recently funded Syracuse Biomaterials Institute REU Site.