SusChEM: New Strategies for Catalytic Couplings, Cycloadditions, and Redox Conversions

在这个由化学部化学合成项目资助的项目中，密歇根大学化学系的John Montgomery教授将探索过渡金属催化偶联和环加成的方法。将制定策略，使羰基活化的底物在偶联中得到利用，在偶联过程中发生脱氧。五元环环加成组装的新策略也将被追求，重点是多组分耦合过程。通过提出的策略，三种简单且广泛可用的成分的组合将提供一系列结构复杂的碳环。虽然具体目标的某些方面将允许对镍和钯催化剂进行比较分析，但大多数努力将涉及利用廉价和现成的镍催化剂。这项工作将为使用第一排金属从简单和容易获得的底物催化组装复杂结构提供见解。这些研究将为环境友好型催化工艺的发展提供新的策略。这些研究的进展可以应用于制药、生物技术、农业、聚合物和石油工业的研究问题。从事这些研究的学生将获得技能，使他们能够成为这些行业的生产成员或在大型大学或本科机构的学术职位。对小型大学学术职位感兴趣的学生同事将有机会与邻近机构的教师开发合作项目。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor John Montgomery of the Department of Chemistry at the University of Michigan will explore the development of methods for transition metal-catalyzed couplings and cycloadditions. Strategies will be developed that enable carbonyl-activated substrates to be utilized in couplings, with deoxygenation occurring during the coupling process. New strategies for the cycloaddition assembly of five-membered rings will also be pursued, with a focus on multicomponent coupling processes. By the proposed strategies, the combination of three simple and widely available components will provide access to a range of structurally complex carbocycles. While some aspects of the specific aims will allow a comparative analysis of nickel and palladium catalysts, the majority of efforts will involve the utilization of inexpensive and readily available nickel catalysts.This work will provide insights into the use of first row metals for the catalytic assembly of complex structures from simple and readily available substrates. New strategies for the development of environmentally benign catalytic processes will be elucidated by these studies. The advances from these studies could be applied to research questions in the pharmaceutical, biotechnology, agricultural, polymer, and petroleum industries. The students engaged in these studies will obtain skills that will enable them to be productive members of these industries or in academic positions at large universities or undergraduate institutions. Student coworkers with an interest in small college academic positions will be given the opportunity to develop collaborative projects with faculty at neighboring institutions.