CAREER: Hemodynamic processes in thrombosis

1150947 Shadden血流改变引起的不当凝血（血栓形成）是几乎所有主要心血管疾病、手术和器械的主要问题。从概念上讲，血流以两种一般方式影响血栓形成：通过施加力和引导运输。 然而，对这些过程的机械理解仍然很差。这一直是一个关键的障碍，在解决为什么某些流量功能相关有利，或不利，血栓events.The项目的目标是开发工具和见解，需要确定的机制，其中局部扰动血流增强病理性凝块形成。这将通过计算血流建模和分析的进步来实现，沿着收集的经验数据，以帮助指导和验证数值结果。这项工作将专门解决如何改变流动导致血栓形成狭窄的动脉，这是心脏病发作和中风的主要原因。最近的研究结果揭示了惊人的和协同的相互作用之间的流体力和运输机制是一致的狭窄血栓的临床观察。有大量的更广泛的潜力，使用该项目开发的工具和见解，以解决什么样的血流动力学条件是重要的，以及如何最好地建模，识别和传达。重要的发现和技术将由伊利诺伊理工学院（IIT）数学和科学教育部门整合到正在进行的STEM课程开发中，以促进K-5学生的工程学，并将其纳入IIT波音学者学院计划。用于支持这项研究的实验模型的设计，制造和测试将被纳入IIT独特的跨专业项目计划，由PI指导。

1150947ShaddenInappropriate clotting (thrombosis) stemming from alterations in blood flow is a primary concern with nearly all major cardiovascular diseases, surgeries, and devices. Conceptually, blood flow influences thrombosis in two general ways: by imparting forces and directing transport. However, mechanistic understandings of these processes remain poorly defined. This has been a critical barrier in addressing why certain flow features correlate favorably, or unfavorably, to thrombotic events.The objective of this project is to develop tools and insights needed to determine the mechanisms by which local disturbances in blood flow potentiate pathological clot formation. This will be accomplished through advancements in computational blood flow modeling and analysis, along with empirical data collected to help guide and validate the numerical findings. This work will specifically address how altered flow leads to thrombus formation in stenotic arteries, which is the primary cause of heart attack and stroke. Recent results have uncovered striking and synergistic interactions between fluid forces and transport mechanisms that are consistent with clinical observations of stenotic thrombus. There is substantial broader potential to use the tools and insights developed by this project to address what hemodynamic conditions are important, and how they are best modeled, identified and conveyed.This project will foster education on several fronts uniquely suited to PI's environment. Important findings and techniques will be integrated by the Illinois Institute of Technology (IIT) Mathematics and Science Education department into ongoing STEM curriculum development to promote engineering to K-5 students, and into the IIT Boeing Scholars Academy Program for Chicagoland high school students. The design, fabrication and testing of experimental models used to support this research will be incorporated into IIT's unique Interprofessional Projects Program, instructed by the PI.