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Actuated Surface Attached Post Systems for Microscale Fluid Dynamics

Actuated Surface Attached Post Systems for Microscale Fluid Dynamics
用于微尺度流体动力学的驱动表面附着柱系统
批准号:
1437751
负责人:
Richard Superfine
金额:
$27.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2014
资助国家:
美国
项目状态:
已结题
起止时间:
2014-08-01 至 2018-07-31

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中文摘要
翻译
主要研究者:Superfine,Richard提案编号:1437751 Myriad生物推进和混合系统即使在高粘性或粘弹性流体中也能有效地工作。在所有这些情况下,大自然都开发了一个共同的解决方案:纤毛。这项研究的目标正是:研究纤毛在微尺度流体流动的推进和混合中的作用。这项工作的结果将适用于在微流体应用中的生物和技术背景下感兴趣的问题。泵送和混合是当前微流体中最关键的技术挑战。由于流动非常缓慢,因此不能支持湍流流体运动,因此流体混合非常缓慢。该研究将回答机械纤毛如何传输粘弹性流体的有趣问题,这可能对微流体/芯片实验室技术领域产生重大影响。微尺度表面附着柱(ASAP)阵列形式的纤毛仿生表示将用于泵送和混合牛顿流体和粘弹性流体(VE)。这些柱将被致动以响应流动。虽然已经做了建模工作的粘性流体,非常少的实验或理论文献存在的微致动器驱动泵在非牛顿流体。通过这项研究要回答的问题是什么力量需要泵送或混合,什么样的拍形状是最有效的,拍频率如何影响泵送?这些问题将回答有关的假设和理论的考虑,并将涉及到粘弹性流体的流变特性。
英文摘要
PI: Superfine, RichardProposal Number: 1437751Myriad biological propulsion and mixing systems operate efficiently even in highly viscous or viscoelastic fluids. In all of these cases, nature has developed a common solution: the cilium. The goal of the proposed study is exactly this: to investigate the role of cilia in propulsion and mixing of fluid flows at the microscale. Results of this work will be applicable to problems of interest in biological and technological contexts in microfluidic applications. Pumping and mixing are the most critical technological challenges in current microfluidics. Since the flows are in the very slow, turbulent fluid motion cannot be supported, and consequently fluid mixing is very slow. The proposed research will answer interesting questions in how mechanical cilia can transport viscoelastic fluids, which may have large impacts on the field of microfluidic/lab on a chip technologies.Biomimetic representations of cilia in the form of microscale surface attached post (ASAP) arrays will be employed to pump and mix Newtonian and viscoelastic (VE) fluids. These posts will be actuated to respond to the flow. Though modeling work has been done for viscous fluids, very little experimental or theoretical literature exists for microactuator driven pumping in non-Newtonian fluids. The questions to be answered through this research are what forces are required for pumping or mixing, what beat shape is most effective and how does the beat frequency affect pumping? These questions will be answered in relation to hypotheses and theoretical considerations, and will be related to the rheological properties of the viscoelastic fluid.
期刊论文(3)
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会议论文
DOI: 10.1088/0960-1317/25/2/025004
发表时间: 2015-02-01
期刊: JOURNAL OF MICROMECHANICS AND MICROENGINEERING
影响因子: 2.3
作者: [Fiser, Briana L., Shields, Adam R., Superfine, R.]
通讯作者: Superfine, R.
Actuated Post Arrays for Integrated Studies of Pumping, Mixing and Free Swimmers
Mechanobiology of Phagocytosis
Computational Cell Motility Model Educed from Single-Cell and High-Throughput Phenotype Analysis
Ciliary Mechanics
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