Expanding the Scope of Donor/Acceptor Carbenoids

有了这个奖项，化学合成项目支持埃默里大学Huw M. L. Davies教授的基础研究。戴维斯教授和他的学生将使用手性催化剂开发新的对映选择性有机合成方法。该研究探索了由金属稳定乙烯基碳烯的葡萄状反应诱导的反应，并具有以对映选择性方式产生全新转化的潜力。乙烯基碳烯的乙烯化反应尚未得到很好的了解，这些研究有望有助于对碳铑化学的基本认识。戴维斯教授将把该项目的研究和教育内容整合到几个新举措中，为学术研究人员创造一个协作和支持的环境。一项新的化学研究和多样性项目正在计划中，该项目将邀请来自少数民族大学的教授和他们的两名学生进行暑期研究项目。一个强大的学生指导计划已经被设计，以确保学生成为专家在他们的特定领域的研究和发展的经验广度和沟通技巧，必要的高效在他们未来的职业生涯。戴维斯教授为他的学生开发了许多拓展活动，如斯佩尔曼期刊俱乐部、科学咖啡馆、亚特兰大科学节、化学创新者系列讲座、视频会议短期课程，以及通过访问工业演讲者进行的职业发展讲座。在本研究中，将探讨金属乙烯基碳烯的合成转化，通过在乙烯基碳烯的葡萄状位置发生初始反应进行。将开发方法，以控制金属乙烯基乙烯的反应活性的位置，要么使用金催化剂或空间体积大的钯催化剂。将研究一些新的具有有限优先级的立体选择方案，包括[4+3]环加成，[4+2]环加成和异位基化，这将为复杂靶分子的快速构建开辟新的可能性。

With this award, the Chemical Synthesis program is supporting fundamental research of Professor Huw M. L. Davies at Emory University. Professor Davies and his students will employ chiral catalysts for the development of new enantioselective methods in organic synthesis. The study explores reactions induced by vinylogous reactions of metal-stabilized vinylcarbenes and has the potential of generating entirely new transformations in an enantioselective manner. The vinylogous reactions of vinylcarbenes are not yet well understood and these studies are expected to contribute to the fundamental understanding of rhodium carbene chemistry. Professor Davies will integrate the research and educational components of this project within several new initiatives for developing a collaborative and supportive environment for academic researchers. A new Chemistry Research & Diversity Program is planned which will bring professors from minority universities with 2 of their students to work on summer research projects. A robust student-mentoring plan has been designed to ensure the students become experts in their specific area of research and develop the breadth of experience and the communication skills necessary to be highly effective in their future careers. Professor Davies has developed many outreach activities available to his students such as the Spelman Journal Club, science cafes, the Atlanta Science Festival, Chemical Innovator Lecture Series, videoconference short courses, and career development lectures by visiting industrial speakers. In this research, synthetic transformations of metal vinylcarbenes, proceeding by an initial reaction occurring at the vinylogous position of the vinylcarbene, will be explored. Methods will be developed to control the site of reactivity of the metal vinylcarbenes by using either gold catalysts or sterically bulky dirhodium catalysts. A number of novel stereoselective protocols of limited prior precedence will be examined, including [4+3] cycloadditions, [4+2] cycloadditions and crotylations, which will open up new possibilities for the rapid construction of complex target molecules.