UNS:A Multi-Element ICP-MS Approach for Detection of Engineered Nanoparticles in the Environment

#1512695兰维尔，詹姆斯F.水，土壤和空气都含有超细颗粒，纳米颗粒，远远小于人类头发的宽度。 大自然不断地创造纳米颗粒，我们现在可能会通过纳米技术的发展来增加微小颗粒的背景。 我们将高度工程化的纳米粒子用于我们的药品、食品、纺织品、防晒霜和许多其他产品中。 该项目旨在利用高度发展的分析方法，沿着沃茨和沉积物取样的发展，检测和量化纳米技术释放的纳米颗粒，并将其与自然产生的纳米颗粒区分开来。该项目将利用新纳米计量学的最新发展来克服挑战（例如，小尺寸、低浓度、干扰性天然纳米颗粒（NNPs））用于定量水生系统中的工程化纳米颗粒（ENPs）。 单粒子ICP-MS（spICP-MS）分析的几种新方法，具有逐粒子检测多种元素的能力，将提供新的数据，使纳米技术的风险评估取得重大进展。 分析方法利用ENP和干扰NNP之间存在的元素组成差异，以提供ENP鉴定和定量。 NNPs中多个元素的检测将使它们与ENPs的更简单（单个）元素检测事件特征区分开来。 将确定当前“背景”地表水NP浓度（颗粒数量、质量）和NP特征（例如，粒度分布、组成）。还将进行由多元素spICP-MS分析促进的异源聚集实验，以确定它如何影响拟议的纳米计量学，并还将提供有关地表水中ENP命运的所需信息。总的来说，这方面的信息目前缺失，但对确定环境卫生和安全影响的ENPs至关重要。 该研究将与两个已建立的研究小组（USGS）和公共教育小组（RiverWatch）合作。所获得的信息预计将（i）减少纳米技术风险评估的不确定性，（ii）提供在美国地质勘探局采样网络内进行ENP分析的框架，最终目标是将QUANT-Nano的方法纳入常规水质监测，（iii）通过在CSM的暑期研究经验和实地考察，我们将培训一批不同的K-12学生和高中科学教师，以“通过开发简单的实验来了解水中的小颗粒。 我们将让这些学生和教育工作者参与监测当地的水资源，以及（iv）教育公众环境监测的重要性，以促进纳米技术的安全发展，

#1512695Ranville, James F.Water, soil, and air all contain ultrafine particles, nanoparticles, that are far smaller than the width of a human hair. Nature creates nanoparticles constantly, and we may now be adding to this background of tiny particles by our development of nanotechnology. We put highly engineered nanoparticles in our medicines, foods, textiles, sunscreens, and many other products. This project seeks to use highly-developed analytical methods, along with developments in sampling of waters and sediments, to detect and quantify the nanoparticles released from nanotechnology and discriminate them from those created naturally.This project will utilize recent developments in new nanometrologies to overcome the challenges (e.g. small size, low concentration, interfering natural NPs (NNPs)) for quantifying engineered nanoparticles (ENPs) in aquatic systems. Several new approaches to single-particle ICP-MS (spICP-MS) analysis, which have the capability to detect multiple elements on a particle-by-particle basis, will provide new data that will allow significant progress in risk assessment of nanotechnology. The analytical approach utilizes elemental composition differences, which exist between ENPs and the interfering NNPs, to provide ENP identification and quantification. The detection of multiple elements in NNPs will distinguish them from the simpler (single) element detection events characteristic of ENPs. The current "background" surface water NP concentrations (particle number, mass) and NP characteristics (e.g. size distribution, composition) will be determined. Heteroaggregation experiments, facilitated by multi-element spICP-MS analysis, will also be performed to establish how it effects the proposed nanometrologies and will also provide needed information on ENP fate in surface water. Collectively, this information is currently missing but critically important for determining the environmental health and safety effects of ENPs. The research will be a collaboration with two established groups in research (USGS) and in public education (RiverWatch). Information acquired is expected to (i) reduce uncertainty in risk assessment of nanotechnology, (ii) provide the framework for performing ENP analysis within the USGS sampling network, with the ultimate goal of incorporating methodology from QUANT-Nano into routine water quality monitoring, (iii) through summer research experiences at CSM and field-trips we will train a diverse group of K-12 students and high school science teachers to "see the invisible" by developing simple experiments that educate about small particles in water. We will involve these students and educators in the monitoring of their local water resources, and (iv) educate the public on the importance of environmental monitoring to facilitate safe development of nanotechnology,