Die Rolle von tertiären lymphatischen Geweben bei Entzündungsreaktionen und entzündlichen Erkrankungen im Darm

淋巴组织的发展概括了炎症反应，最终形成复杂的淋巴组织聚集体。肠道中淋巴结和佩耶尔补丁的发育是程序化的，是在胎儿的无菌环境中开始的。相反，三级淋巴组织的形成是由感染引起的。慢性炎症还导致三级淋巴组织的形成，其中许多不同类型的细胞相互作用，如B细胞、T细胞、骨髓细胞和基质细胞。该项目的目标是了解导致三级淋巴组织形成的机制及其对炎症性疾病的影响。为了实现这一目标，我将使用现有的小鼠模型，并开发新的转基因方法来研究肠道炎症背景下三级淋巴组织形成的现象。该项目的具体目标是：(1)确定三级淋巴组织形成的炎症触发因素，并可视化三级淋巴组织形成过程中的分子和细胞相互作用。(2)通过阻断淋巴组织的形成来预防肠道炎症。长期目标是开发新的和特定的工具来控制病理性炎症，例如发生在炎症性肠病，类风湿性关节炎或多发性硬化症中的炎症。

The development of lymphoid tissues recapitulates the inflammatory reaction and culminates in the formation of complex lymphoid aggregates. The development of lymph nodes and Peyer¿s patches in the gut is programmed and is initiated in the sterile environment of the fetus. In contrast, the formation of tertiary lymphoid tissues is induced by infection. Chronic inflammation also leads to tertiary lymphoid tissue formation, in which many different cells types interact, such as B cells, T cells, myeloid and stromal cells. The goal of this project is to understand the mechanisms that lead to formation of tertiary lymphoid tissues and their impact on inflammatory disease. To achieve this, I will use existing mouse models and also develop new transgenic approaches to examine the phenomena of tertiary lymphoid tissue formation in the context of intestinal inflammation. The specific aims of this project are to (1) identify the inflammatory triggers of tertiary lymphoid tissue formation and visualize the molecular and cellular interactions during tertiary lymphoid tissue formation. (2) to prevent intestinal inflammation by blocking the formation of lymphoid tissues. The long-term aim is to develop new and specific tools for the control of pathologic inflammation, such as occurs in inflammatory bowel disease, rheumatoid arthritis or multiple sclerosis.