MRI: Acquisition of a 400 MHz NMR Spectrometer for Research and Education

有了来自主要研究仪器计划（MRI）的这一奖项和化学研究仪器计划（CRIF）的支持，瓦萨学院将获得400 MHz NMR光谱仪。该仪器将允许在不同领域进行研究，包括合成具有潜在商业利益的材料，如碳纳米管，富勒烯和小分子，这些材料是药物的潜在前体。生物化学领域的利益，如脂质的生物合成将进行调查。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。 该仪器将成为瓦萨学院、马里斯特学院、纽约州立大学新广场分校和该地区其他本科院校学生进行教学和研究的一个组成部分。该提案旨在加强研究，特别是在以下领域：（a）甘油磷脂结构表征;（B）研究钛介导的不对称亚胺烷基化;（c）吡咯烷取代富勒烯表征;（d）开发可生物降解的聚酸酐材料;（e）研究含有共面噻吩取代喹喔啉环的C形非对映体。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Vassar College will acquire a 400 MHz NMR spectrometer. The instrument will allow research in different areas including the synthesis of materials of potential commercial interest such as of carbon nanotubes, fullerenes and small molecules which are potential precursors to pharmaceuticals. Areas of biochemical interest such as the biosynthesis of lipids will be investigated. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument will be an integral part of teaching as well as research performed by students at Vassar College, Marist College, SUNY New Platz and other undergraduate institutions in the area. The proposal is aimed at enhancing research especially in areas such as (a) characterizing glycerophospholipid structures; (b) investigating titanium-mediated asymmetric imine alkylation; (c) charactering pyrrolidine substituted fullerenes; (d) developing biodegradable polyanhydride materials; and (e) studying C-Shaped diastereomers containing cofacial thiophene-substituted quinoxaline rings.