EAGER: Implantable Particle-Based Wireless Neurorecording Probes for Minimally-Intrusive 3D Mapping of Brain Signals

建议编号：1550743：EIGER：可植入粒子的无线神经记录探头用于脑信号的最小侵入性3D映射在过去30年中，神经记录探头技术一直使用针状电极阵列来实现。针在神经组织中的存在会导致广泛的损伤和炎症，从而导致疤痕组织的形成，并最终导致探头失败。这项工作建议使用电极阵列放置在亚毫米的仪表化球形颗粒的表面。因此，小的、无小腿的颗粒允许在插入后愈合周围组织，最大限度地减少疤痕组织的形成，并延长探头的寿命。这项新技术在实现基础脑功能研究、脑与机器接口和神经假体的仪器方面具有广泛的适用性。拟议的工作分为四个独立的任务：(1)开发新的微制造技术，以构建带有外围电极的中空、球形微囊；(2)开发超紧凑型折叠CMOS神经记录电路；(3)开发紧凑型射频生物遥测电路；(4)在小动物身上测试基于粒子的探针的有效性、组织损伤和寿命。

Proposal No:1550743: EAGER: Implantable Particle-Based Wireless Neurorecording Probes for Minimally-Intrusive 3D Mapping of Brain SignalsFor the last thirty years neurorecording probe technologies have been implemented using arrays of needle like electrodes. The presence of needles in neural tissue causes extensive damage and inflammation that lead to scar tissue formation and eventual probe failure. This work proposes the use of electrodes arrays placed on the surface of sub-mm, instrumented spherical particles. The small, shank free particles thus allow for the healing of surrounding tissue after insertion minimizing scar tissue formation and extending probe life. This new technology has broad applicability in the realization of instrumentation for fundamental brain function studies, brain to machine interfaces and neural prostheses.The proposed work is divided into four separate tasks: (1) the development of new microfabrication technologies for construction of hollow, spherical micro-capsules with peripheral electrodes, (2) the development of ultracompact folded CMOS neurorecording circuits, (3) the development of compact RF biotelemetry circuits and (4) the testing of effectiveness, tissue damage and longevity of particle-based probes on small animals.