CAREER: SusChEM: New Methods for Cu-Catalyzed Cross-Coupling Reactions

美国印第安纳大学化学系的Michael K. Brown教授在化学催化项目（CAREER）中介绍了碳-碳键催化构建的新方法，这是现代有机化学的一个重要目标。这项研究的首要目标是利用廉价的铜（Cu）催化剂来辅助合成有用的分子，如新药。这种新的催化方法通过使用第一排（非贵金属）铜催化剂来促进可持续性。这种催化剂比贵金属催化剂含量更丰富，毒性更小，对环境的危害更小。通过开展引人入胜的以化学为主题的课堂活动，以及评估、改进和复制一个由布朗实验室最近开发的儿童博物馆的永久性化学主题展览，教育目标得以实现。这些活动将一个已知的概念，气味，和一些未知的东西，化学结构，引入并联系起来。布朗教授的努力满足了科学教育的两个需求：在科学博物馆开展以化学为主题的展览，以及向儿童介绍化学。Brown教授正在开发两类铜催化碳-碳键形成的方法：1)suzuki - miyaura型交叉偶联反应，2)suzuki - miyaura型交叉偶联反应被烯烃打断。这些方法的实施使学术界和工业界的化学家能够获得以前难以制备的复杂分子支架。预计这些研究的影响和知识价值如下：1)为suzuki - miyaura型交叉偶联引入廉价，可持续的cu催化剂；2)发现易于获得的未活化烯烃功能化的新方法；3)发现与cu催化剂反应的新模式。这项研究通过使用第一行（非贵金属）铜催化剂来促进可持续化学。教育目标是通过发展有趣和吸引人的有机化学主题课堂活动，并通过评估、改进和复制一个由布朗实验室最近开发的儿童博物馆的永久性有机化学主题展览来实现的。这些活动将一个已知的概念，气味，和一些未知的东西，化学结构，引入并联系起来。作为他项目的教育部分，布朗教授正在开发一些材料，用来教育K-6年级的孩子们关于分子结构和有机化学的基本概念。

In this (CAREER) project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Michael K. Brown of the Department of Chemistry at Indiana University is introducing new methods for the catalytic construction of carbon-carbon bonds, which is an important objective in modern organic chemistry. The overarching goal of this research is to utilize inexpensive copper (Cu)-catalysts to assist in the synthesis of useful molecules such as new pharmaceutical agents. This new catalytic method promotes sustainability by using first row (non-precious metal) copper catalysts. Such catalyst are more abundant, less toxic and less environmentally harmful than precious metal catalysts. The educational goal is accomplished by developing engaging chemistry-themed classroom activities and by evaluating, improving and replicating a permanent chemistry-themed exhibit at a children's museum recently developed by the Brown Lab. These activities introduce and connect a known concept, smell, to something unknown, chemical structure. Professor Brown's efforts meet two needs in science education: development of chemistry-themed exhibits at science museums, and introduction of chemistry to children at a young age.Professor Brown is developing two general classes of Cu-catalyzed methods for carbon-carbon bond formation: 1) Suzuki-Miyaura-type cross-coupling reactions, and 2) Suzuki-Miyaura-type cross-coupling reactions that are interrupted by an alkene. Implementation of these methods enables chemists in academia and industry to access complex molecular scaffolds that were previously difficult to prepare. The impacts and intellectual merit of these studies are expected to be the following: 1) introduction of inexpensive, sustainable Cu-catalysts for Suzuki-Miyaura-type cross-couplings, 2) discovery of new methods for the functionalization of readily available unactivated alkenes, and 3) uncovering new modes of reactivity with Cu-catalysts. This research promotes sustainable chemistry by using first row (non-precious metal) copper catalysts. The educational goal is accomplished by developing fun and engaging organic chemistry-themed classroom activities and by evaluating, improving and replicating a permanent organic chemistry themed exhibit at a children's museum recently developed by the Brown Lab. These activities introduce and connect a known concept, smell, to something unknown, chemical structure. As the educational component of his project, Professor Brown is developing materials that educate children in grades K-6 about very basic concepts related to molecular structure and organic chemistry.