MRI: Acquisition of a 500 MHz State-of-the-Art Nuclear Magnetic Resonance (NMR)Spectrometer

MRI：购买 500 MHz 最先进的核磁共振 (NMR) 波谱仪

• 批准号: 1920026
• 负责人: Michael Brown
• 金额: $ 66.79万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1920026&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; State

This award is supported by the Major Research Instrumentation and the Chemistry Instrumentation Programs. Professor Michael Brown from Indiana University and colleagues Nicola Pohl, Amar Flood, Jeremy Smith and Silas Cook are acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as facilitating studies of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The NMR studies improve understanding of synthetic organic/inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research. This broadly accessible instrumentation strengthens the regional NMR analytical infrastructure and help advance the scientific careers of many undergraduate and graduate researchers, postdocs and visiting scholars in several research groups. The spectrometer enriches the education and training experience of underrepresented undergraduate students in several NSF supported science, technology, engineering and mathematics (STEM) programs and is used to enrich activities at a local children's museum. The award is aimed at enhancing research and education at all levels. The spectrometer is especially used for developing reactions for the preparation of organic molecules to be further studied for potential therapeutic activity and for determining the affinity of host-guest complexes. It is also employed by researchers interested in obtaining mechanistic insight into electrochemical nitrogen oxides reduction which is relevant in the production of ammonia and other industrially and physiologically important products as well as for carrying out natural product structure determination on microscale. The nuclear magnetic resonance spectrometer and associated instrumentation is also used for characterization of products obtained from high-throughput microscale reactions involving biocatalytic carbon-hydrogen functionalization and for studying NMR in catalytic design. It is also used by researchers carrying out high-throughput evaluation of glycosylation reactions which are controlled enzymatic modifications of organic molecules (especially proteins) by addition of sugar molecules.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学仪器计划支持。来自印第安纳州大学的迈克尔·布朗教授和他的同事尼古拉·波尔、阿马尔·弗拉德、杰里米·史密斯和塞拉斯·库克正在购买一台500兆赫的核磁共振（NMR）光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及促进生物相关物种的研究。一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。NMR研究提高了对合成有机/无机化学，材料化学和生物化学的理解。该仪器是教学和研究的一个组成部分。这种广泛使用的仪器加强了区域NMR分析基础设施，并有助于推动许多本科生和研究生研究人员，博士后和访问学者在几个研究小组的科学事业。光谱仪丰富了在几个NSF支持的科学，技术，工程和数学（STEM）计划中代表性不足的本科生的教育和培训经验，并用于丰富当地儿童博物馆的活动。该奖项旨在加强各级的研究和教育。该光谱仪特别用于开发用于制备有机分子的反应，以进一步研究潜在的治疗活性，并用于确定主客体复合物的亲和力。它也被感兴趣的研究人员用于获得对电化学氮氧化物还原的机理洞察，这与氨和其他工业和生理学重要产品的生产以及进行天然产物结构测定有关。核磁共振光谱仪和相关仪器还用于表征从涉及生物催化碳-氢官能化的高通量微型反应中获得的产物，并用于研究催化设计中的NMR。该奖项也被研究人员用于对糖基化反应进行高通量评估，糖基化反应是通过添加糖分子对有机分子（特别是蛋白质）进行受控酶促修饰。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估而被认为值得支持。

项目成果

Flavin-dependent halogenases catalyze enantioselective olefin halocyclization.

• DOI: 10.1038/s41467-021-23503-3
• 发表时间: 2021-06-01
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Mondal D;Fisher BF;Jiang Y;Lewis JC
• 通讯作者: Lewis JC

Stereoselective [2+2]-Cycloadditions of chiral allenic ketones and alkenes: Applications towards the synthesis of benzocyclobutenes and endiandric acids

• DOI: 10.1016/j.tet.2022.132932
• 发表时间: 2022-08-26
• 期刊: TETRAHEDRON
• 影响因子: 2.1
• 作者: Guo，Renyu;Witherspoon，Brittany P.;Brown，M. Kevin
• 通讯作者: Brown，M. Kevin