Organic Acids, Bases, Catalysts, and Anion Recognition Reagents

本课题由化学系化学结构与动力学机制B项目资助，由Steven R.明尼苏达大学化学系的卡斯研究电荷增强的酸、碱和氢键催化剂。 这项研究的目标是开发新的和有用的催化剂，并更好地了解这些物种如何运作，以促进其发展。 在我们日常生活中所需的化学品的制备过程中，需要更有效的催化剂，例如药品和聚合物的生产。 该项目位于有机，物理和分析化学的界面，特别适合教育和培训年轻科学家。 NSF支持的这组工作已经获得了两项专利，并且从人类健康和环境到农业和化学工业的大量实际应用可能来自这项研究。电荷增强的酸，碱和氢键催化剂（盐）正在制备和表征中。它们的催化能力正在各种有机转化中进行研究，并且正在探索结构变化以增加它们的反应性。 正在研究在这些盐基催化剂中的远程位置共价结合的抗衡离子的作用。 手性底物（例如，硫脲、二醇、二醇衍生的磷酸和生物碱碱），并测定它们的对映选择性。 具有手性抗衡离子的双立体分化催化剂也正在研究中。

In this project funded by the Chemical Structure, Dynamic & Mechanism B Program of the Chemistry Division, Professor Steven R. Kass of the Department of Chemistry at the University of Minnesota explores charge-enhanced acids, bases, hydrogen bond catalysts. The goal of this research is to develop new and useful catalysts, and obtain a better understanding of how these species operate to facilitate their development. More efficient catalysts are needed in the preparation of chemicals required in our daily life, such as the production of pharmaceuticals and polymers. This project lies at the interface of organic, physical, and analytical chemistry, and is particularly well suited for educating and training young scientists. Two patents have resulted from NSF-supported work in this group and a wealth of practical applications ranging from human health and the environment to agriculture and chemical industry may arise from this research.Charge-enhanced acids, bases, and hydrogen bond catalysts (salts) are being prepared and characterized. Their catalytic abilities are being examined in a variety of organic transformations, and structural variations are being probed to increase their reactivity. The role of covalent incorporation of the counterion at a remote location in these salt based catalysts are being studied. Chiral substrates (e.g., thioureas, binols, binol-derived phosphoric acids, and alkaloid bases) are being prepared and their enantioselectivities are being determined. Catalysts with chiral counterions for double stereodifferentiation are also being investigated.