Allosterically Regulated Supramolecular Capsules and Receptors Assembled via the WLA

在这个由大分子、超分子和纳米化学项目资助的项目中，ChadA。西北大学的Mirkin正在开发合成特殊分子的设计规则，这些分子可以作为胶囊，具有可控的尺寸和识别特性，用于检测器，分子分离和催化。这些胶囊的合理设计和合成是超分子结构组装领域的重大挑战，可以导致与临床医学中必需的药物的纯化、对化学和石油工业重要的低价值化学原料向高价值化学原料的转化、以及对环境测试和食品包装领域至关重要的化学传感器的开发。具体而言，该项目的重点是开发刺激响应异二聚体胶囊，使用强大的和可推广的化学，可以在各种各样的设置中实施。各种胶囊正在合成和研究的背景下的薄弱环节的方法，和最有前途的正在进一步使用X射线晶体学，多核NMR光谱，等温滴定量热法，质谱和紫外可见光谱的特点。这些新型异二聚体胶囊的化学和物理性质正在通过与西北大学综合分子结构教育和研究中心（IMSERC）等核心设施的合作来定义。米尔金建立了旨在吸引当地高中生和来自世界各地的本科生的外联方案。这些计划侧重于指导学生，教他们实验室研究的技术方面，并为他们的学术生涯的下一阶段做好准备。这些年轻的学生正在学习该领域最前沿的科学研究，并与领先的科学家，研究生和博士后研究人员进行互动。这项工作为年轻学生，包括代表性不足的少数民族提供了一个培训基地，并为他们提供了开发技术所必需的基本科学知识，这些技术可以显着改善许多美国人的生活。

In this project, funded by the Macromolecular, Supramolecular and Nanochemistry program, Professor Chad A. Mirkin of Northwestern University is developing design rules for the synthesis of special molecules that can serve as capsules with controllable size and recognition properties for applications in detectors, molecular separations, and catalysis. The rational design and synthesis of these capsules, is a significant challenge in the field of the assembly of supramolecular structures, could lead to significant advances related to the purification of pharmaceuticals essential in clinical medicine, the conversion of low-value to high-value chemical feedstocks important to the chemical and petroleum industries, and the development of chemical sensors critical to the environmental testing and food packaging fields. Specifically, this project focuses on the development of stimuli-responsive heterodimeric capsules, using robust and generalizable chemistry that can be implemented in a wide variety of settings. Various capsules are being synthesized and studied in the context of the Weak-Link approach, and the most promising are being characterized further using X-ray crystallography, multinuclear NMR spectroscopy, isothermal titration calorimetry, mass spectrometry, and UV-vis spectroscopy. The chemical and physical properties of these novel heterodimeric capsules are being defined through collaborative efforts with core facilities, such as the Integrated Molecular Structure Education and Research Center (IMSERC), at Northwestern University. Outreach programs aimed at engaging local high school students and undergraduates from around the world have been established by Mirkin. These programs focus on mentoring students, teaching them technical aspects of laboratory research, and preparing them for the next stage of their academic careers. These young students are learning about scientific research at the forefront of the field and interacting with leading scientists, graduate students, and postdoctoral researchers. This work provides a training ground for young students, including underrepresented minorities, and equips them with basic science knowledge essential for developing technologies that can significantly improve the lives of many Americans.