MRI: Upgrade of a 600 MHz Spectrometer for high-sensitivity Nuclear Magnetic Resonance (NMR)

该奖项由主要研究仪器和化学研究仪器计划支持。来自查佩尔山的北卡罗来纳州大学的Jeffrey约翰逊教授和同事加里·皮拉克、亚历山大米勒、吉利安·邓普西和Bo Li升级了600 MHz NMR光谱仪的控制台，并为光谱仪配备了低温平台，以提高灵敏度。这将把一台旧仪器改造成一台现代化的光谱仪.这款升级后的光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及研究生物相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。相对于允许使用小样品的标准NMR探针，低温探针提供了灵敏度的显著增加。该仪器用于该大学和邻近学校的研究和研究培训。该提案旨在加强各级的研究和教育。它特别影响了原料化学品的复杂性建设反应的研究，以及太阳能燃料生产中质子耦合电子转移的利用。光谱仪用于研究量子点，探索微生物天然产物的结构和功能多样性，以及鉴定新的微生物天然产物。升级后的仪器还用于表征天然产物途径中的生物合成中间体，并用于探测可持续有机金属催化的机制。细胞中的氟NMR用于探测球状蛋白质。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation, and the Chemistry Research Instrumentation programs. Professor Jeffrey Johnson from University of North Carolina at Chapel Hill and colleagues Gary Pielak, Alexander Miller, Jillian Dempsey and Bo Li have upgraded the console of a 600 MHz NMR spectrometer and have equipped the spectrometer with a cryoplatform to allow higher sensitivity. This will transform and old instrument into a modern spectrometer. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permits use of small samples. The instrument is used for research and research training at this university and neighboring schools. The proposal is aimed at enhancing research and education at all levels. It especially impacts studies of complexity-building reactions from feedstock chemicals as well as utilization of proton-coupled electron transfer in solar fuel production. The spectrometer is used to investigate quantum dots and in the exploration of structural and functional diversity of microbial natural products and in the identification of new microbial natural products. The upgraded instrument is also employed in characterizing biosynthetic intermediates in natural product pathways and for probing mechanisms in sustainable organometallic catalysis. Fluorine NMR in cells is used to probe globular proteins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.