Meeting: The -omics of chemical interactions in simple extant animals ; Society for Integrative and Comparative Biology, Tampa, Florida, January 3-7, 2019

本次研讨会将汇集来自不同背景、领域、研究所和职业阶段的研究人员，彼此交流，并与与会者交流。研讨会的主题是“后基因组时代揭示的早期分化的后生动物对生物和非生物环境的化学反应”。演讲者和主题的互动将激发新的见解，假设和合作。反过来，这些将促进该领域的进展。讨论会将有一个sicb主办的网站，作为关于研究人员及其工作的所有方面的信息储存库。作为本次研讨会的主要成果，至少有11篇同行评议的出版物以及补充数据将发表在《综合与比较生物学》杂志上。由于60%的演讲者是女性，本次研讨会坚定致力于推动女性在科学领域的职业发展以及在高等教育和研究领域的就业。补充会议将为早期职业研究人员提供一个平台，以传播与专题讨论会主题有关的研究。这次研讨会将为未来许多年的学生和研究人员提供资源。现存的早期分化后生动物（刺胞动物、栉虫、Placozoa和Porifera）在一个不断变化和日益复杂的世界中生存下来，而组学数据为这些动物所使用的肽和小分子的多样性提供了新的见解。很明显，令人惊讶的复杂基因库使基础后生动物能够编码许多与“高等”动物相关的信号、感觉、防御和攻击能力。现在是时候考虑组学方法如何通过关注这些简单动物如何进化出对环境刺激的多种化学反应来解决环境和化学序列如何在基础后生动物中塑造表型。本次研讨会的目的是发展后基因组的形式，功能和化合物的起源，是生物合成的早期分化后生动物响应环境线索的观点。受邀演讲者将在三个主要领域进行演讲：1)感知的分子基础，2)用于处理生物和非生物环境的化学物质，以及3)表征宿主，寄生虫和共生体密切相互作用的分子交叉对话。将考虑的具体主题包括：毒素多样性、生活方式和化学物质的选择、免疫分子、细胞接收的化学和简单动物的感官复杂性。本次研讨会的主题和演讲者的互动将有助于比较功能生物化学的发展，揭示化学介质如何使缺乏复杂形态，解剖和行为的简单动物在地质时期的持久性和多样化。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This symposium will bring together researchers from diverse backgrounds, fields, institutes and career stages to engage with each other and with conference attendees. The topic of the symposia is "Chemical responses to the biotic and abiotic environment by early diverging metazoans revealed in the post-genomic age." The interaction of speakers and topics will stimulate new insights, hypotheses and collaborations. In turn, these will enhance progress in the field. The symposium will have a SICB-hosted website that will serve as a repository for information on all aspects of the researchers and their work. A minimum of 11 peer-reviewed publications, along with supplementary data, will be published in the journal Integrative and Comparative Biology as major products of the symposium. The symposium has a strong commitment to advancing the careers of women in science and employment in higher education and research, as 60% of the speakers are women. A complementary session will provide a platform for early career researchers to disseminate research related to the theme of the symposium. The symposium will lead to development of resources that will be available to students and researchers for many years to come. Extant early-diverging metazoans (Cnidaria, Ctenophora, Placozoa, and Porifera) have survived in a changing and increasingly complex world, and -omics data are providing novel insights on a diversity of peptides and small molecules that these animals deploy. It is clear that surprisingly sophisticated gene repertoires enable basal metazoans to encode many of the signaling, sensory, defensive and offensive capacities associated with "higher" animals. It is now timely to consider how omics methods can be used to resolve how environmental and chemical queues shape phenotypes among the basal metazoans by focusing on how these simple animals have evolved a diversity of chemical responses to environmental stimuli. The aim of this symposium is to develop a post-genomic view on the form, functions and origins of compounds that are biosynthesized in early diverging metazoans in response to environmental cues. Invited speakers will contribute talks in three general areas: 1) the molecular basis of perception, 2) chemicals deployed to deal with the biotic and abiotic environment, and 3) the molecular cross-talk that characterizes intimate interactions of hosts, parasites and symbionts. Specific topics that will be considered include: toxin diversity, life styles and co-option of chemicals, immune molecules, the chemistry of cellular reception, and sensory complexity in simple animals. The topics of this symposium and resulting interactions of speakers will contribute to a growing picture of comparative functional biochemistry, revealing how chemical mediators have enabled persistence and diversification of simple animals that lack sophisticated morphologies, anatomies and behaviors over geological time.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.