CAS: New Strategies for Sustainable Methods in Nickel-Catalyzed Coupling Reactions

有了这一奖项，美国国家科学基金会化学部的化学合成计划正在支持密歇根大学的约翰·蒙哥马利教授的研究。蒙哥马利教授与研究生和本科生合作，开发进行有机合成的改进方法。这些方法包括确定如何将简单和容易获得的原料转化为高价值的合成化合物，并确定新的催化剂，以提高所开发的合成方法的合成效率和实用性。此外，这些方法使用地球上丰富的金属来降低成本，并将危险副产品的形成降至最低。这种综合改进可以应用于许多环境中，包括学术实验室和制药、生物技术、农业、聚合物和石油行业。蒙哥马利教授高度致力于包容性教学实践和探索创新方法，将他的研究、教学和推广重点整合到他的研究小组中。蒙哥马利教授通过他开发的一个班级继续与第一代/代表不足的少数族裔学生合作。更广泛的社会影响包括开展外联活动，这些活动将提供社区联系，鼓励年轻学生对自己的成功能力充满信心，并在他们的教育道路和职业选择中考虑STEM领域。蒙哥马利教授和他的学生开发了新的镍催化剂，使发现和开发合成工艺能够快速获得高价值产品。芳基硅醚和烯醇硅烷作为合成中的多用途底物的发展使新的断开成为可能，这些断开提供了不寻常的和合成上强大的进入高价值产品结构的入口。这些方法是对常用的反应性有机金属加成亲电羰基化合物的重要补充。这项研究的一个重要方面是使用容易获得、稳定和高活性的镍(0)催化剂，这些催化剂可以被许多研究领域的非专业人员广泛应用。这些方法可能为有机合成提供新的方法和战略，使高价值结构的快速、高效、选择性和成本效益的准备成为可能。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor John Montgomery of the University of Michigan. Professor Montgomery works with graduate students and undergraduates to develop improved ways to conduct organic synthesis. The approaches involve identifying ways to convert simple and readily available feedstocks into high value synthetic compounds and to identify new catalysts that improve the synthetic efficiency and practicality of the synthetic methods developed. Additionally, the methods use earth abundant metals to reduce cost and minimize the formation of hazardous by-products. The synthetic improvements can be applied in a number of settings including academic labs and pharmaceutical, biotechnology, agricultural, polymer, and petroleum industries. Professor Montgomery is highly committed to inclusive teaching practices and the exploration of innovative ways to integrate his research, teaching, and outreach focus within his research group. Professor Montgomery continues working with first-generation/underrepresented minority students via a class he developed. Broader societal impacts include development of outreach activities that will provide community connections that encourage young students to be confident in their ability to succeed and to consider STEM fields as they navigate their educational paths and career choices. Professor Montgomery and his students develop new nickel catalysts that enable the discovery and development of synthetic processes that provide rapid access to high-value products. The development of aryl silyl ethers and enol silanes as versatile substrates in synthesis enable novel disconnections that provide unusual and synthetically-powerful entries to high value product structures. These methods provide an important complement to the commonly employed addition of reactive organometallics to electrophilic carbonyls. An integral aspect of the research is the use of readily available, stable, and highly active nickel(0) catalysts that can be broadly applied by non-specialists in many fields of research. The methods may provide new approaches and strategies for organic synthesis that enable the rapid, efficient, selective, and cost-effective preparation of high-value structures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.