MRI: Acquisition of a Quadrupole/Time-of-Flight Mass Spectrometer with Ion Mobility Separations for Faculty and Student Research in the Susquehanna Valley

该奖项由主要研究仪器项目和化学研究仪器项目支持。巴克内尔大学正在购买一台高压液体色谱仪离子迁移率四极杆质谱仪(HPLC-IM-Q-TOF)，以支持萨斯奎汉纳大学的道格拉斯·柯林斯教授及其同事莫里亚·钱伯斯和卢·汤姆。通常，质谱仪是用于识别和表征复杂样品中的少量化学物种的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被制成离子，并测量离子的质量。这种高度灵敏的技术使研究复杂混合物中的分子结构成为可能。带有液体色谱仪的仪器可以在混合物到达质谱计的分析器之前将其分离。离子迁移率(IM)组件提供了一种根据气相离子与气体的相互作用来分离气相离子的方法，该方法取决于它们的质量。最初，离子被快速分离，然后它们被引入质量分析仪。这种复杂的仪器对分析人体样本(蛋白质组学和代谢组学)很有用。此次收购加强了大学和地区的研究基础设施。该仪器使不同的学生能够熟悉这种现代分析技术，从而扩大了参与度。在萨斯奎哈纳大学的学生参加的外展活动中也使用了高效液相色谱-即时消息-Q-TOF。授予质谱计的目的是加强各级的研究和教育。它尤其影响了超分子主客体化学的探索和多孔的机理研究，以及结晶共价有机骨架(COF)的形成。该仪器用于通过金属相互作用控制多肽的二级结构。此外，它还为理解复杂有机薄膜的多相化学提供了信息。质谱仪被用来研究室内表面的三手烟的影响以及药物的光降解。该仪器也被用于识别萤火虫中的抗菌剂。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Bucknell University is acquiring a high-pressure liquid-chromatograph ion mobility, quadrupole mass spectrometer (HPLC-IM-Q-TOF) to support Professor Douglas Collins and colleagues Moria Chambers and Lou Tom from Susquehanna University. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are made into ions and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer's analyzer. The ion mobility (IM) component provides a method that separates gas phase ions based on their interactions with a gas depending on their masses. Initially, the ions are quickly separated and then they are introduced into the mass analyzer. This complex instrument is useful to analyze samples from the human body (proteomics and metabolomics). The acquisition strengthens the research infrastructure at the university and regional area. The instrument broadens participation by enabling diverse students to gain familiarity with this modern analytical technique. The HPLC-IM-Q-TOF is also used in outreach activities involving students from Susquehanna University.The award of the mass spectrometer is aimed at enhancing research and education at all levels. It especially impacts exploration of supramolecular host-guest chemistry and mechanistic studies of porous and the formation of crystalline covalent organic frameworks (COF). The instrumentation is used for controlling peptide secondary structure through metal interactions. In addition, it provides information to understand multiphase chemistry of complex organic films. The mass spectrometer is used to explore the effect of third hand smoke on indoor surfaces and for the study of photodegradation of pharmaceuticals. This instrument is also used in the identification of antimicrobials in fireflies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.