Systembiologische Analysen des Krebsgenoms mit Hilfe deduktiver Datenbanken

该项目的目标是开发一个演绎数据库系统，能够集成各种类型和来源的高维分子肿瘤数据集。因此，我们通过联合研究不同的分子方面，例如基因组数据和表达数据，来接近对癌细胞的系统生物学观点。此外，该系统不仅使用户能够存储和分析他自己的研究数据，而且还提供与来自癌症基因组学其他研究数据储存库的数据的比较视图。这将极大地扩大研究数据分析中可用的信息范围，并使科学调查能够采用新的方法。该系统将在公共实例中实现，其中根据各自的使用限制，每个人都可以访问数据和分析选项。另一方面，每个机构可以根据需要操作自己的本地实例，以使用系统非公开存储和分析自己的研究数据。

The goal of this project is to develop a deductive database system enabling the integration of various types and sources of highdimensional molecular tumor data sets. We thereby approach a systems biology view on cancer cells by a joint investigation of different molecular aspects given e.g. by genomic data and expression data. Furthermore, the system does not only enable the user to store and analyze his own research data, but also provides a comparative view with data from other research data repositories for cancer genomics. This will highly increase the scope of information available in the analysis of research data and enable novel approaches in scientific investigation. The system will be realized in a public instance in which the data and analysis options are accessible to everyone according to the respective restrictions of usage. On the other hand, each institution can operate its own local instance as needed to use the system for the nonpublic storage and analysis of its own research data.